Masateru Taniguchi

High-throughput, high-accuracy detection of emerging viruses allows for the control of disease outbreaks. Currently, reverse transcription-polymerase chain reaction (RT-PCR) is currently the most-widely used technology to diagnose the presence of SARS-CoV-2. However, RT-PCR requires the extraction of viral RNA from clinical specimens to obtain high sensitivity. Here, we report a method for detecting novel coronaviruses with high sensitivity by using nanopores together with artificial intelligenc

The manufacture of integrated circuits with single-molecule building blocks is a goal of molecular electronics. While research in the past has been limited to bulk experiments on self-assembled monolayers, advances in technology have now enabled us to fabricate single-molecule junctions. This has led to significant progress in understanding electron transport in molecular systems at the single-molecule level and the concomitant emergence of new device concepts. Here, we review recent development

Lack of an appropriate method for wiring molecules that have controlled functions and structures has been a barrier for the development of molecular devices. We developed an interconnect method to program three kinds of component molecules with their own functions and to wire a molecular device in a self-organized manner. By using the interconnect method we developed, we produced conductive wires and optical switching devices and have demonstrated their device functions. Our interconnect method

The symmetry of a molecule junction has been shown to play a significant role in determining the conductance of the molecule, but the details of how conductance changes with symmetry have heretofore been unknown. Herein, we investigate a naphthalenedithiol single-molecule system in which sulfur atoms from the molecule are anchored to two facing gold electrodes. In the studied system, the highest single-molecule conductance, for a molecule junction of 1,4-symmetry, is 110 times larger than the lo

We have fabricated an all-solid state and vertical electrochemical transistor, which employs poly(3-hexylthiophene) and cyanoethylpullulan as the semiconducting layer and solid electrolyte, respectively. The device has the same structure as a vertical field effect transistor, but can function using a different mechanism of operation in which the doping and dedoping to polythiophene are controlled by the gate voltage and the source–drain current is modulated by the doping–dedoping process. The tr

We report the use of electrical measurements to identify simultaneously the number and type of organic molecules within metal-molecule-metal junctions. Our strategy combines analyses of single-molecule conductance and inelastic electron tunneling spectra, exploiting a nanofabricated mechanically controllable break junction. We found that the peak linewidth of the inelastic electron tunneling spectrum decreased as the modulation voltage and temperature decreased, and that the selection rule for i

ADVERTISEMENT RETURN TO ISSUEPREVReviewNEXTSelective Multidetection Using NanoporesMasateru Taniguchi*View Author Information The Institute of Scientific and Industrial Research, Osaka University, 8-1 Mihogaoka, Ibaraki, Osaka 567-0047, Japan*E-mail: [email protected]Cite this: Anal. Chem. 2015, 87, 1, 188–199Publication Date (Web):November 11, 2014Publication History Published online19 November 2014Published inissue 6 January 2015https://pubs.acs.org/doi/10.1021/ac504186mhttps://doi.org/10.1021

We synthesized gating nanopores with embedded nanogap electrodes in a solid-state nanopore using an 11-step nanofabrication process. We were able to detect Au nanoparticles passing through a 30-nm-diameter gating nanopore via an electric current between nanoelectrodes. The electric current was proportional to the duration of translocation time. The gating nanopore is expected to be a next-generated nanosystem that can be applied to single-molecule sensors.

Electrode-embedded nanopores have been developed to realize label-free, low-cost, and high-throughput DNA sequencers.