Keio University · Medicine
마사야 나카무라 교수의 연구실은 척수손상 치료를 위한 만성 신경손상 모델에서의 줄기세포 치료 전략 개발에 초점을 맞추고 있습니다. 인간 induced pluripotent stem cell 유래 신경줄기세포(hipSC-NS/PCs)와 올리고덴드로사이트 전구세포를 이용한 이식 치료의 안전성과 유효성을 비임상 모델(원숭이 포함)에서 검증하고 있으며, 특히 신경재생 및 축삭 재세포화를 통한 기능적 회복 메커니즘을 규명하고자 합니다. 이와 함께 임상 적용을 위한 안전성 확보와 병행해, 장기적인 통증 관리와 연계된 신경재생 전략도 탐색하고 있습니다.
Figures are computed from collected data and may differ slightly.
Murine and human iPSC-NS/PCs (induced pluripotent stem cell-derived neural stem/progenitor cells) promote functional recovery following transplantation into the injured spinal cord in rodents. However, for clinical applicability, it is critical to obtain proof of the concept regarding the efficacy of grafted human iPSC-NS/PCs (hiPSC-NS/PCs) for the repair of spinal cord injury (SCI) in a non-human primate model. This study used a pre-evaluated "safe" hiPSC-NS/PC clone and an adult common marmose
Chronic musculoskeletal pain does not necessarily improve even with prolonged treatment. It adversely affects daily life and both physical and mental health. Because those suffering pain often increasingly need assistance in daily activities, people around them are also affected. The therapeutic system and treatment procedures for chronic musculoskeletal pain merit prompt review.
Murine- and human-induced pluripotent stem cell-derived neural stem/progenitor cells (iPSC-NS/PCs) promote functional recovery following transplantation into the injured spinal cord in rodents and primates. Although remyelination of spared demyelinated axons is a critical mechanism in the regeneration of the injured spinal cord, human iPSC-NS/PCs predominantly differentiate into neurons both in vitro and in vivo. We therefore took advantage of our recently developed protocol to obtain human-indu
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We plan to start recruiting a patient as soon as the COVID-19 epidemic subsides. The primary focus of this clinical study is safety, and the number of transplanted cells may be too low to confirm efficacy. After confirming safety, a dose-escalation study is planned.
Transplantation of neural stem/progenitor cells (NS/PCs) following the sub-acute phase of spinal cord injury (SCI) has been shown to promote functional recovery in rodent models. However, the types of cells most effective for treating SCI have not been clarified. Taking advantage of our recently established neurosphere-based culture system of ES cell-derived NS/PCs, in which primary neurospheres (PNS) and passaged secondary neurospheres (SNS) exhibit neurogenic and gliogenic potentials, respecti
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