Hokkaido University · Medicine
Professor Mitsuyoshi Takiguchi's research lab specializes in veterinary clinical pathology and translational medicine, focusing on identifying novel biomarkers and diagnostic tools for canine diseases. The lab investigates inflammatory and fibrotic conditions such as inflammatory bowel disease (IBD), hepatic fibrosis, and chronic kidney disease, with an emphasis on serum markers like C-reactive protein and serine. They also explore the role of micronutrients—particularly vitamin D—in cardiac remodeling and disease progression. Advanced imaging techniques, including 2D shear wave elastography (2D-SWE), are employed to non-invasively assess organ fibrosis in dogs.
Figures are computed from collected data and may differ slightly.
C-reactive protein (CRP) was isolated from equine serum by use of calcium-dependent affinity chromatography conjugated pneumococcal C-polysaccharide, anion exchange chromatography, and gel filtration. It was identified as genuine CRP by its immunochemical cross-reactivity with anti-human CRP, its homology with human CRP in amino acid composition, and its pentameric structure as revealed by electron microscopy. Purified equine CRP had a molecular weight of approximately 118,000 and was composed o
Dogs that respond to ULFD management and are diagnosed with FR-PLE are expected to have a favorable prognosis. Clinical scores, specifically the CCECAI, could be useful for differentiating FR-PLE from IR-PLE or NR-PLE.
Plasma serine concentration might represent a novel maker of IBD in dogs.
Polypoid cystitis is a rare disease of the urinary bladder in dogs characterized by chronic inflammation, epithelial proliferation, and development of a polypoid mass or masses without histopathologic evidence of neoplasia. The ultrasonographic appearances of eight dogs with polypoid cystitis are described. Ultrasonography confirmed the presence of a bladder mass or masses in all patients. Ultrasonographic findings are mucosal projections and a polypoid to pedunculated mass of variable size and
The 2D-SWE may be useful for predicting the presence of hepatic fibrosis in dogs with hepatic disease.
These results indicate that vitamin D status is associated with the degree of cardiac remodeling, and the serum 25(OH)D concentration begins to decrease before the onset of heart failure in dogs with CVHD.
The PI and AUC can detect duodenal inflammation and hence are potentially useful for excluding a diagnosis of CIE.
A three-year-old, intact male, Siberian husky was evaluated for a two day history of dysuria. Sonographically there was an anechoic cyst-like structure in the urinary bladder. The abnormality appeared to be a 'cyst within a cyst', which is a characteristic ultrasonographic feature of ureterocele in humans. Ultrasonography may be a useful means of establishing a diagnosis of ureterocele in dogs.
CEUS parameters PI and AUC can provide useful information in differentiating acute pancreatitis from normal pancreas. Cerulein-induced AP was characterized by prolonged hyperechoic enhancement on CEUS.
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