Keio University · Medicine
Professor Murat Doğru's research lab focuses on ocular surface diseases, particularly dry eye disease and meibomian gland dysfunction (MGD), with an emphasis on understanding the underlying pathophysiology, improving diagnostic techniques, and developing targeted therapeutic strategies. The lab investigates the role of oxidative stress in ocular surface damage and explores antioxidant-based treatments, while also advancing clinical tools such as strip meniscometry for objective assessment. A key goal is establishing international consensus on MGD classification and management to improve patient outcomes.
Figures are computed from collected data and may differ slightly.
DOI:10.1167/iovs.10-6997a Investigative Ophthalmology & Visual Science, Special Issue 2011, Vol. 52, No. 4 Copyright 2011 The Association for Research in Vision and Ophthalmology, Inc. 1922 ドライアイ疾患の原因としては、マイボーム腺機能不全 (MGD)がおそらく最も多い。この疾患によって数百万人 もの健康と幸福が損なわれているにもかかわらず、MGD の定 義、分類、診断、治療について世界的なコンセンサスはない。 そうしたコンセンサスに達する目的で、非営利団体である Tear Film and Ocular Surface Society( TFOS; http://www. tearfilm.org)が International Workshop on Meibomian Gland Dysfunction(国際マイボーム腺機能不全ワークショップ、 www.tearfilm.org/mgdwork
Reactive oxygen species (ROS) are produced as a by-product during the mitochondrial respiration of the oxygen and potentially able to damage the tissues. Oxidative stress occurs as a result of the disruption of the balance between the anti-oxidant system and the pro-oxidant system found in cells. It has been accepted that overexpression of ROS can be induced in the ocular surface as a result of many acute and chronic diseases and even in normal aging. Recent studies demonstrated that oxidative s
Strip meniscometry is a swift, noninvasive, promising new method that is expected to find application in the diagnosis and evaluation of the outcome of treatment of dry eye syndromes.
Although PTK is a safe and efficient method for the treatment of superficial corneal opacities, induced hyperopia after the procedure remains a major problem. A shallow ablation depth (less than 100 microm), presence of a TZ setting, and use of a masking agent decrease the hyperopic shift significantly.
dry eye is a visually disabling disease, the treatment of which needs tailoring according to the type and severity of dry eye disease.
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