Keio University · Medicine
Professor Naohisa Yahagi's research lab specializes in advanced endoscopic techniques for gastrointestinal tumor management, with a primary focus on endoscopic submucosal dissection (ESD) for gastric and duodenal neoplasms. The lab develops innovative endoscopic devices and methods—such as the tip of an electrosurgical snare and the water pressure method—to enhance en bloc resection rates while minimizing complications like bleeding and perforation. Research also emphasizes the healing process of artificial ulcers after ESD and the impact of genetic polymorphisms on chemotherapy toxicity, particularly in pediatric oncology. The lab is committed to advancing standardization and training in ESD to improve global outcomes in gastrointestinal endoscopy.
Figures are computed from collected data and may differ slightly.
Background: Although the strip biopsy method and aspiration method are popular endoscopic mucosal resection techniques for its convenience and reliability, they have limitations in resectable tumor size and location. Endoscopic submucosal dissection techniques using the diathermic needle knife or the insulated‐tip diathermic knife have been introduced to overcome this disadvantage, but they have high risks for bleeding and perforation. Therefore, we have developed a new endoscopic submucosal dis
Further development of the technique, devices and training systems will promote worldwide standardization of ESD.
Background: Due to the remarkable progress of endoscopic resection techniques, endoscopic submucosal dissection (ESD) has been widely performed for larger mucosal tumors that would result in large artificial ulcers. The healing process of peptic ulcers has been previously studied in detail; however, no precise investigation for artificial ulcers after ESD has been reported. To confirm the validity of the treatment from the aspect of wound healing, we aimed to clarify the healing process of large ga
The authors investigated whether high-dose methotrexate-induced toxicity differed according to the presence of methylenetetrahydrofolate reductase (MTHFR) or reduced folate carrier 1 (RFC1) genetic polymorphism. The authors studied 15 children with acute lymphoblastic leukemia or lymphoblastic lymphoma who were treated using protocols that included high-dose methotrexate (3.0 g/m), for an overall total of 43 courses. Methotrexate-induced toxicities and the plasma methotrexate concentrations were
Duodenal endoscopic submucosal dissection (ESD) is difficult due to insufficient mucosal elevation, because of the coarse submucosal layer [1]. We report on the "water pressure method" for duodenal ESD.
ABSTRACT Scheduled piecemeal resection has been actively conducted for granular type laterally spreading tumor (LST‐G) in Japan, as long as a definite preoperative diagnosis is made. However, en bloc resection is desirable for depressed lesions (e.g. IIc lesion) as well as non‐granular type laterally spreading tumor (LST‐NG) since they have considerable high risk for submucoasl invasion and require precise histopathological evaluation. Endoscopic submucosal dissection (ESD) has been developed fo
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