Yonsei University · Medicine
Professor Sang Hoon Ahn's research lab focuses on chronic hepatitis B virus (HBV) infection, with a primary emphasis on understanding the molecular and clinical aspects of viral persistence, liver fibrosis progression, and the development of hepatocellular carcinoma. The lab investigates host-virus interactions, viral genotypes, and the role of covalently closed circular DNA (cccDNA) in viral reactivation after treatment cessation. They also explore non-invasive imaging and biomarkers—such as elastography and tumor characteristics—for predicting disease outcomes and guiding clinical decision-making in both surgical and non-surgical patients.
Figures are computed from collected data and may differ slightly.
TE can be performed with good diagnostic accuracy for quantifying liver fibrosis in patients with CHB.
Although chronic HBV infection is the leading cause of chronic liver disease and death worldwide, there are substantial differences in its clinical courses regarding prevalence, mode of transmission, characteristics of each phase, responses to antiviral therapy, and development of cirrhosis and hepatocellular carcinoma, according to geographical areas (Asia versus Western Europe and North America versus Africa). Furthermore, the clinical course in infected individuals depends on a complex interp
Chronic hepatitis B virus (HBV) infection is a major global health problem. It can cause progressive liver fibrosis leading to cirrhosis with end-stage liver disease, and a markedly increased risk of hepatocellular carcinoma. In the last two decades, substantial progress has been made in the treatment of chronic hepatitis, B. However, HBV is often reactivated after stopping nucloes(t)ide analogues because antivirals alone do not directly target covalently closed circular DNA, which is the templa
Preoperative predictors of microvascular invasion are tumor size, number, and Edmondson grade, which may be useful for making clinical decisions in both non-surgical and surgical candidates.
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