Yonsei University · Medicine
Professor Sang Hui Chu's research lab focuses on metabolic health, inflammation, and lifestyle-related diseases, with a particular emphasis on obesity, metabolic syndrome, and cardiovascular risk factors. The lab investigates biomarkers such as chemerin and adiponectin in relation to systemic inflammation and insulin resistance, while also exploring dietary patterns—particularly the Mediterranean diet—through culturally adapted tools like the Korean-MEDAS. Additional research directions include medication adherence, patient-reported outcomes in heart failure, and the molecular mechanisms of chronic infections like *H. pylori* in gastric cell apoptosis. The lab integrates clinical, nutritional, and molecular approaches to improve preventive and personalized healthcare strategies.
Figures are computed from collected data and may differ slightly.
Obesity and metabolic syndrome (MetS) are considered chronic inflammatory states. Chemerin, a novel adipokine, may play an important role in linking MetS and inflammation. We investigated the association of chemerin with inflammatory markers and with characteristics of MetS in apparently healthy overweight and obese adults. We studied 92 adults; 59 men and 33 women whose average body mass index (BMI) was 28.15 ± 5.08 kg/m(2). Anthropometric parameters, insulin resistance indices, lipid profiles,
An awareness of CTs and the perceptions toward CTs were associated with general public willingness to participate in a CT. Findings from this study can be used in planning outreach and recruitment strategies, and to understand the predictors of CT participation.
The MLHFQ was better able to differentiate sex, comorbidity, and functional status. Further studies are needed to implement cost-effective nursing interventions for patients with CHF to improve their HRQOL.
The Mediterranean diet (MD) has beneficial effects on cardiovascular diseases, cancer, and mortality. Although various attempts have been made for estimating adherence to the MD using diet quality indices, few studies involving validated questionnaires for estimating adherence have been performed in Asian populations. We aimed to develop and validate the Korean version of the Mediterranean Diet Adherence Screener (K-MEDAS) by including 211 participants that visited health check-up centers and 11
When medication adherence was defined as taking warfarin according to medical advice (frequency, dosage, time, and precautions), 56 (27.5%) of 204 respondents were adherent. The adherent group had a greater understanding about warfarin than the nonadherent group as measured by 10 survey items (7.20 ± 1.70 vs 6.56 ± 1.84; P < .05) and had significantly higher self-efficacy (P < .000). However, medication adherence was not associated with good anticoagulation level as measured by INR. The results
Down-regulation of Bcl-2 is mediated by NF-κB activation, which may be the underlying mechanism of apoptosis in H. pylori-infected gastric epithelial cells.
Our results indicate that high burden from symptoms might be associated with lower QoL in GI cancer survivors, and higher economic burden from cancer treatment was associated with lower QoL. These results suggest that symptom management and support for economic difficulties should be included in the strategies to enhance the QoL of GI cancer survivors.
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