The University of Osaka · Dentistry
Professor Satoshi Imazato's research lab specializes in the development of bioactive dental materials with a focus on incorporating antibacterial monomers—particularly methacryloyloxydodecylpyridinium bromide (MDPB)—into resin-based restoratives. The lab pioneers non-releasing antibacterial composites and adhesive systems that maintain mechanical integrity while providing long-term inhibition of cariogenic bacteria such as *Streptococcus mutans* and *Lactobacillus* species. Research also extends to bioactive materials like hydroxyapatite/soluble calcium phosphate composites (HAp/SCaP) that promote osteoblast activity and tissue regeneration. The overarching goal is to create next-generation dental materials that prevent secondary caries and enhance tissue integration through smart, functional monomers and biomaterials.
Figures are computed from collected data and may differ slightly.
Attempts to produce resin composite with antibacterial properties by incorporation of an antibacterial agent such as chlorhexidine have been reported, but problems can arise due to release of the inhibitory agent from the composite. Such problems may include toxic effects, influence on mechanical properties, and loss of effectiveness. A new monomer, methacryloyloxydodecylpyridinium bromide (MDPB), was synthesized by combining an antibacterial agent and methacryloyl group. The monomer was incorpo
Restorative materials in the new era should be "bio-active", and antibacterial effects are highlighted as one of the important properties. In order to achieve resin-based restoratives with antibacterial effects, an antibacterial monomer MDPB has been developed. The primer incorporating MDPB demonstrated cavity-disinfecting effects, and the world's first antibacterial adhesive system employing the MDPB-containing primer was successfully commercialized. MDPB is potentially applicable to various re
The polymerizable monomer methacryloyloxydodecylpyridinium bromide (MDPB) shows antibacterial activity when immobilized in a resin-based material. In this study, the antibacterial effect of a dentin primer incorporating MDPB was investigated. The influence of incorporation of MDPB on bond strength to dentin and on the curing performance of the adhesive system was also evaluated. Experimental primers were prepared by addition of MDPB into a proprietary primer at 1, 2, or 5%. Antibacterial effects
The aim of this study was to investigate the bactericidal effect of a dentin primer incorporating the antibacterial monomer 12-methacryloyloxydodecylpyridinium bromide (MDPB) against bacteria in human dentinal carious lesions. To evaluate the antibacterial activity of MDPB against anaerobes, the minimum inhibitory concentration (MIC) and the minimum bactericidal concentration (MBC) against obligate anaerobes and facultative anaerobic strains of lactobacilli were determined. Bacteria were recover
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