Yonsei University · Medicine
Professor Seok-Min Kang's research lab focuses on calcium signaling in cancer biology, particularly the role of IP3 receptor subtype 3 in glioblastoma invasion and survival. The lab also investigates cardiovascular protection in heart failure patients with end-stage renal disease, exploring the therapeutic potential of sodium bicarbonate and other interventions. Additionally, the lab examines environmental stressors such as thermal stress and their physiological impacts on poultry, with a focus on thermoregulation and panting responses. A growing interest in the interplay between metabolic hormones like leptin and vascular remodeling further expands the lab’s scope into angiogenesis and vascular inflammation in atherosclerosis.
Figures are computed from collected data and may differ slightly.
Calcium (Ca<sup>2+</sup>) signaling is an important signaling process, implicated in cancer cell proliferation and motility of the deadly glioblastomas that aggressively invade neighboring brain tissue. We have previously demonstrated that caffeine blocks glioblastoma invasion and extends survival by inhibiting Ca<sup>2+</sup> release channel inositol 1,4,5-trisphosphate receptor (IP<sub>3</sub>R) subtype 3. Trifluoperazine (TFP) is an FDA-approved antipsychotic drug for schizophrenia. Interesti
We found that SV could safely reduce the hsTnT and sST2 levels and improve LVEF in HFrEF patients with ESRD. As far as we know, this is the first study to show the efficacy and safety of SV in HFrEF with ESRD on dialysis. Larger prospective, long-term follow-up study should be warranted.
This study was conducted to evaluate the effects of temperature-humidity index (THI) on the mortality and the panting rates in hens exposed to varying thermal environments. Hens were challenged with an acute elevation in THI in Experiment 1, where dry-bulb temperature and relative humidity were set at ~27°C and 56% at the beginning of the experiment and changed to 36°C and 45% at its conclusion, respectively. In Experiment 2, different groups of hens were exposed to a progressive increase in THI
Neovascularization of the adventitial vasa vasorum with extension into the intima of atherosclerotic lesions is frequently observed, but its pathophysiological significance is still subject to debate. Recently, leptin, the product of the Ob gene, was identified. Leptin, via activation of the endothelial receptor (Ob-R), generates a growth signal involving a tyrosine kinase-dependent intracellular pathway and promotes angiogenic processes. We hypothesized that a high concentration of leptin withi
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