Yonsei University · Medicine
Professor Seon-Jin Yoon's research lab specializes in translational neuro-oncology, focusing on the tumor microenvironment, cancer stem cells, and patient-specific modeling of glioblastoma (GBM) and gastric cancer. The lab investigates cellular origins, molecular drivers, and microenvironmental interactions using single-cell technologies, patient-derived models, and microfluidic platforms to decode tumor heterogeneity and therapy resistance. Key research directions include identifying cancer-promoting cell types such as tumor mesenchymal stem-like cells (tMSLCs), elucidating the role of genes like CD34, EGFR, and IDH1 in tumor morphology and progression, and developing personalized therapeutic strategies through organoid and perfusion-based culture systems. The lab aims to bridge preclinical findings with clinical applications by integrating molecular profiling with functional assays in real-time patient-derived tissues.
Figures are computed from collected data and may differ slightly.
Suppression of CD34 in the human-originated gastric cancer cell suggests that it is important for the round-void histologic shape, heterogeneous enhancement pattern on MRI, and the growth of gastric cancer cell line.
Glioblastoma (GBM) is a disease without any definite cure. Numerous approaches have been tested in efforts to conquer this brain disease, but patients invariably experience recurrence or develop resistance to treatment. New surgical tools, carefully chosen samples, and experimental methods are enabling discoveries at single-cell resolution. The present article reviews the cell-of-origin of isocitrate dehydrogenase (IDH)-wildtype GBM, beginning with the historical background for focusing on cellu
The isolation from brain tumors of tumor mesenchymal stem-like cells (tMSLCs) suggests that these cells play a role in creating a microenvironment for tumor initiation and progression. The clinical characteristics of patients with primary glioblastoma (pGBM) positive for tMSLCs have not been determined. This study analyzed samples from 82 patients with pGBM who had undergone tumor removal, pathological diagnosis, and isolation of tMSLC from April 2009 to October 2014. Survival, extent of resecti
No difference in the clinical outcomes and systemic complications at discharge and after six months of follow-up was observed between the two groups. However, favorable outcomes in the no AED group showed a slight increase after six months. These findings suggest that discontinuation of the current practice of using prophylactic AED might be recommended in patients with a good clinical grade.
Patient-specific cancer therapies can evolve by vitalizing the mother tissue-like cancer niche, cellular profile, genetic signature, and drug responsiveness. This evolution has enabled the elucidation of a key mechanism along with development of the mechanism-driven therapy. After surgical treatment, glioblastoma (GBM) patients require prompt therapy within 14 days in a patient-specific manner. Hence, this study approaches direct culture of GBM patient tissue (1 mm diameter) in a microchannel ne
GBM tissue level expression patterns of EGFR, TERT, PTEN, IDH1, PTPRZ1, and MGMT are observed in the GBM TSs. The driver gene-associated cluster of the GBM single cells were enriched with the glioma-associated long noncoding RNAs.
Abstract An increasing number of studies indicate air pollutants infiltrate into the brain. We aimed to find the association of cumulative air pollution exposure in the main body of primary brain tumor: glioblastoma (GBM). In this double‐cohort, retrospective analysis study with a protocol, we compared the health effect of air pollution on the GBM patients from the SEER (Surveillance, Epidemiology, and End Results Program) in 27 U.S. counties from 10 states and GBM patients of Severance cohort o
PD MR showed sufficient contrast difference to distinguish paraclinoid aneurysms from surrounding dural structures.
We extracted the carbon monoxide (CO) data, or vertically integrated CO column density (unit, mol/m^2 ; with "CO_column_number_density" as the band variable). And we summarized the TROPOMI extracted CO data in rds format (R data serialization format).
Tumor mesenchymal stem-like cells (tMSLCs) can be isolated from high grade gliomas and also play a role in a glioma progression as a participant in the tumor microenvironment. tMSLCs were known to have an effect on the overall survival of primary glioblastoma patients. However, Isolation rate of tMSLCs from surgical specimen was inconstant and the yield was not guaranteed. With a presumption that a relationship might exists between the weight of the sample and the yield rate, we assessed fifty-o
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