Sungkyunkwan University · Medicine
Professor Seung Hwan Moon's research lab specializes in nuclear medicine and molecular imaging, with a primary focus on utilizing (18)F-fluorodeoxyglucose (FDG) positron emission tomography (PET/CT) to improve cancer prognosis, staging, and treatment planning. The lab investigates metabolic parameters such as total lesion glycolysis (TLG) and standardized uptake value (SUV) to predict survival outcomes and treatment response in various malignancies, including nasopharyngeal carcinoma, squamous cell carcinoma of the tonsil, and NK/T-cell lymphoma. Additionally, the lab explores the metabolic link between systemic diseases like nonalcoholic fatty liver disease (NAFLD) and subclinical vascular inflammation, highlighting the broader implications of FDG-PET in metabolic and cardiovascular risk assessment.
Figures are computed from collected data and may differ slightly.
Accurate prediction of cancer prognosis before the start of treatment is important since these predictions often affect the choice of treatment. Prognosis is usually based on anatomical staging and other clinical factors. However, the conventional system is not sufficient to accurately and reliably determine prognosis. Metabolic parameters measured by (18)F-fluorodeoxyglucose (FDG) positron emission tomography (PET) have the potential to provide valuable information regarding prognosis and treat
TLG is a significant independent metabolic prognostic factor for overall survival in patients with SCC of the tonsil.
Our study demonstrated that (18)F-FDG PET/CT scanning is a valuable modality for staging and treatment planning in patients with nasal-type NK/T-cell lymphoma.
We assessed the association between nonalcoholic fatty liver disease (NAFLD) and carotid artery inflammation measured by (18)F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography. Participants were 755 consecutive otherwise healthy adult males who underwent a general health screening program. Carotid FDG uptake, represented as maximum target-to-background ratio, was increased with mild (n = 237; 1.61 ± 0.14; P = .033) and moderate NAFLD (n = 145; 1.63 ± 0.16; P = .005) comp
The TLG of the primary tumor was a significant independent metabolic prognostic factor of DFS in patients with NPC treated with CCRT.
SUV max, combined with clinical T classification, may be useful for predicting occult lymph node metastasis in patients with clinically N0 squamous cell carcinoma of the esophagus.
This study investigated the associations between image features extracted from tumor <sup>18</sup>F-fluorodeoxyglucose (FDG) uptake and genetic alterations in patients with lung cancer. A total of 137 patients (age, 62.7 ± 10.2 years) who underwent FDG positron emission tomography/computed tomography (PET/CT) and targeted deep sequencing analysis for a tumor lesion, comprising 61 adenocarcinoma (ADC), 31 squamous cell carcinoma (SQCC), and 45 small cell lung cancer (SCLC) patients, were enrolled
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