Waseda University · Medicine
Professor Seung-Taek Lim's research lab focuses on the intersection of physical activity, metabolic health, and aging, with a particular emphasis on how lifestyle factors such as exercise, sleep patterns, and chronotype influence metabolic syndrome, insulin sensitivity, and age-related functional decline. The lab investigates the molecular and physiological mechanisms underlying sarcopenia, β-cell dysfunction, and adipose tissue metabolism, especially in pre-diabetic and elderly populations. Key research directions include the impact of resistance and aerobic exercise on cognitive reserve, lipolysis, and body composition, as well as genetic factors such as COL5A1 polymorphisms in relation to physical performance and metabolic health in Asian populations.
Figures are computed from collected data and may differ slightly.
This study indicates that related poor sleep quality and late-type chronotype may reduce the athletes' performance in elite athletes. In addition, the sleep quality is much higher in the early-type chronotype than in the late-type chronotype. Moreover, it also the athletic performance was better in the early-type chronotype than in the late-type chronotype.
The prevalence of metabolic syndrome (MetS) risk factors among the Korean population requires effective health surveillance and examination of the effects of preventative behaviors. Thus, the objective of this study is to evaluate the relationships between the clustering of MetS and MVPA in a large sample of 36,987 Koreans ranging from 20 to 80 years of age. This study recruited a total of 36,987 adults (23,813 males and 13,174 females). All participants were assessed for moderate-to-vigorous ph
Aging is characterized by the gradual deterioration of function at the molecular, cellular, tissue, and organism levels in humans. The typical diseases caused by changes in body composition, as well as functional decline in the human body's organs due to aging include sarcopenia and metabolic disorders. The accumulation of dysfunctional aging β cells with age can cause decreased glucose tolerance and diabetes. Muscle decline has a multifactorial origin, involving lifestyle habits, disease trigge
We concluded that COL5A1 gene polymorphism is associated with increased SLR ROM in Asian population.
Physical exercise may stimulate lipolytic activity within adipose tissue. Furthermore, resistance exercise may contribute to the more efficient reduction in adipose tissue mass and prevent the accumulation thereof in obese women. The purpose of this study was to examine the effects of regular resistance exercise for 12 weeks on the lipolysis pathway in women with obesity. Twenty-three pre- and postmenopausal women with body fat percentages of 30% or more were divided into the premenopausal group
The purpose of this study was to investigate the change in cognitive reserve biomarkers of the pre-diabetic individual according to the types of leisure-time physical activity (aerobic or resistance physical activity). The research subjects (n = 184) who participated in the survey were pre-diabetic and diabetic patients who were visiting university hospitals and welfare centers. The intervention subjects (n = 36) who were elderly females with pre-diabetes volunteered to participate in the study
This study provides robust evidence that disabled older adults individuals who do not meet the recommended guidelines for PA or who do not participate in PA at least once a week have an increased likelihood of cognitive impairment compared to those who are regularly active.
The purpose of this study was to investigate changes in the levels of myokines in post- menopausal obese females (PMOF) after regular aerobic and resistance training. A community-based, randomized controlled trial study of 41 PMOF from Buk-gu Community Center in Chuncheon, Gangwon-do, Republic of Korea, was conducted from November 2017 through October 2018. These participants were randomly assigned to an aerobic exercise group (n = 21) or a resistance exercise group (n = 20). The 12-week exercis
[Purpose] The aim of our study was to investigate the association between COL5A1 genotype and Range of Motion as measured by the passive straight leg raise (SLR) and whole body join laxity (WBJL) in Asian population. [Methods] One hundred and seventy seven participants including Korean and Japanese college students (male = 109, female = 68) participated in the study. Each subject performed the passive straight leg raise and whole body join laxity test. Genotyping for the COL5A1 (rs 12722) polymo
We herein report a case of gingival candidiasis in an advanced gastric cancer patient while receiving palliative cytotoxic chemotherapy. A 46-year-old male patient admitted to our hospital for known advanced gastric cancer with newly developed multiple liver metastases. While receiving 2nd line cytotoxic chemotherapy with 5FU, leucovorin, and paclitxel, he complained of gingival swelling accompanied by pain and whitish plaque. Due to lack of response to the conservative oral care, incisional bio
The purpose of this study was to investigate the survey of sports injury and to provide basic data for injury prevention in college baseball players, survey was classified into injured part, injured tissue, causes of damage during competition and training. Eighty-five college baseball players (33 pitchers, 35 infielders, 17 outfielders) registered in Korean Sport & Olympic Committee who surveyed. Pitchers in the competition were waist (12.86%), shoulder joint (12.86%), elbow joint (11.43%), and
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