The University of Osaka · Medicine
Shungo Hikoso 교수의 연구실은 심장질환, 특히 심부전의 발달 기전을 규명하는 데 초점을 맞추고 있습니다. 주로 NF-kappaB 및 STAT6와 같은 전사 인자들이 심장세포 사멸과 심장 기능 저하에 미치는 영향을 동물 모델을 활용해 연구하고 있으며, 압력 과부하 상태에서의 세포 신호전달 경로의 역할을 생체 내에서 규명하고자 합니다. 특히 심장세포의 생존과 사멸을 조절하는 분자 기전에 대한 기초 연구를 중심으로 심장질환의 새로운 치료 타겟을 모색하고 있습니다.
Figures are computed from collected data and may differ slightly.
Cardiomyocyte death plays an important role in the pathogenesis of heart failure. The nuclear factor (NF)-kappaB signaling pathway regulates cell death, however, the effect of NF-kappaB pathway on cell death can vary in different cells or stimuli. The purpose of the present study was to clarify the in vivo role of the NF-kappaB pathway in response to pressure overload. First, we subjected C57Bl6/J mice to pressure overload by means of transverse aortic constriction (TAC) and examined the activit
The protocol was approved by the Institutional Review Board (IRB) of Osaka University Hospital on 24 February 2016 (ID: 15471), and by the IRBs of the all participating facilities. The findings will be disseminated through peer-reviewed publications and conference presentations.
STAT6 plays a protective role against hemodynamic stress in hearts.
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