The University of Tokyo · Medicine
Professor Sumito Ogawa's research lab focuses on molecular mechanisms underlying age-related diseases, with a particular emphasis on the roles of nuclear receptors, transcriptional regulation, and hormonal signaling in sarcopenia and cognitive decline. The lab investigates novel estrogen receptor isoforms, such as ERbetacx, and their functional implications in human physiology and pathology, as well as the involvement of corepressor complexes like NCoR/SMRT in transcriptional control relevant to aging and inflammation. Current research also explores the impact of lifestyle and nutritional factors on neurodegenerative processes and muscle function in aging. The lab integrates molecular biology, cell biology, and translational approaches to uncover therapeutic targets for age-related disorders.
Figures are computed from collected data and may differ slightly.
We have identified and characterized a novel human estrogen receptor (ER) beta isoform, ERbetacx, which is truncated at the C-terminal region but has an extra 26 amino acids due to alternative splicing. The ERbetacx transcript is expressed in testis, ovary, thymus and prostate as well as in human cultured cell lines such as HEC-1, HOS-TE85 and Saos-2 cells. ERbetacx protein is also immunodetectable in these human cells. Biochemical analysis reveals that the average dissociation constants ( K d)
The nuclear receptor corepressor (NCoR) and the related factor known as silencing mediator of retinoic acid and thyroid hormone receptor (SMRT) are essential components of multiprotein complexes that mediate active repression by unliganded nuclear receptors. Recent studies suggest that NCoR and SMRT can interact with and exert repressive effects on several other classes of DNA-binding transcription factors, but the physiological importance of these interactions has not been established. Here, in
Age-related loss of the skeletal muscle and its function is known as sarcopenia. Definition and diagnostic criteria for sarcopenia have been outlined as consensus statements from several study groups, including usual gait speed, grip strength, and skeletal muscle mass. Whereas underlying mechanisms and pathophysiology of sarcopenia remains to be clarified, recent studies have suggested that chronic inflammatory status as well as lifestyle-related factors in older individuals might contribute to
Age-related cognitive decline is a main predictor of disability among elderly people, and with the continued expansion of the aging population and the increase in life expectancy, the prevalence of mild cognitive impairment and dementia represented by Alzheimer's disease (AD), which is a multifactorial neurodegenerative disorder of older adults, have increased. Recent epidemiological and observational studies suggest a relationship exists between lifestyle factors, including nutrition and diet,
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