Kyung Hee University · Medicine
Professor Sun Young Kim's research lab focuses on translational biomedical research with a strong emphasis on aging-related diseases, particularly sarcopenia and osteoporosis in the elderly Korean population. The lab integrates clinical epidemiology, body composition analysis using DXA, and biomarker discovery to identify early indicators of muscle and bone health decline. Additionally, the lab explores bioactive natural compounds from traditional medicinal plants for their antiplatelet and anticoagulant properties, aiming to develop novel therapeutics for cardiovascular protection. The research also extends to synthetic organic chemistry, including transition-metal-catalyzed cyclization reactions for the efficient construction of complex carbocyclic and heterocyclic frameworks with potential pharmaceutical relevance.
Figures are computed from collected data and may differ slightly.
The optimal cut-off values of CC for low MM are 35 cm for males and 33 cm for females. Lower CC based on these cut-off values is related with poor physical function. CC may be also a good indicator of sarcopenia in Korean elderly.
The purpose of this study was to predict osteoporosis risk as decreasing muscle mass and to declare the cut-off value of low muscle mass in an elderly Korean population. This study was based on data from the 2008-2010 Korea National Health and Nutritional Examination Surveys (KNHANES). The subjects included 1,308 men and 1,171 women over 65 yr. Bone mineral density (BMD) and appendicular skeletal muscle (ASM) were measured by dual energy X-ray absorptiometry (DXA), and appendicular skeletal musc
Choose your catalyst wisely: Depending on the position of the cyclopropyl substituent on the bicyclo[4.1.0]hept-2-ene substrate, a different rhodium complex was used to catalyze the title reaction, which leads to bicyclic dienones in reasonable to excellent yields (see scheme). The products contain a highly substituted seven-membered ring with useful functionality for further manipulation. R1=H, Me; R2=H, Me, Ph; R3=Me, Et; X=NR, O.
Cinnamomum cassia is a well-known traditional medicine for improvement of blood circulation. An extract of this plant showed both platelet anti-aggregation and blood anti-coagulation effects in preliminary testing. Among the 13 compounds obtained from this plant, eugenol (2), amygdalactone (4), cinnamic alcohol (5), 2-hydroxycinnamaldehyde (7), 2-methoxycinnamaldehyde (8), and coniferaldehyde (9) showed 1.5-73-fold greater inhibitory effects than acetylsalicylic acid (ASA) on arachidonic acid (A
Enyne-enyne-o: Tandem cycloisomerization of dienynes catalyzed by platinum dichloride and subsequent Cope rearrangement affords bicyclic rings (see scheme; Z=NTs, O, CH2), such as bicyclo[3.2.2]nonadienes 1 or tetrahydrocyclohepta[c]pyrans and -pyridines 2, in high yields.
Rapid, spatially compatible, localized thinning of the retinal nerve fiber layer after the first detected DH was shown by Stratus OCT.
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