Yonsei University · Medicine
Professor Sung Kwan Shin's research lab specializes in viral oncology and molecular carcinogenesis, with a primary focus on the role of human polyomaviruses—particularly JC virus (JCV)—in the development of gastrointestinal cancers. The lab investigates viral oncoproteins such as T-antigen (T-Ag) and their mechanisms in disrupting cellular signaling pathways that lead to tumorigenesis. Current research also explores the potential of viral oncoproteins as biomarkers and therapeutic targets in gastric cancer.
Figures are computed from collected data and may differ slightly.
Endoscopic resection is a safe and effective modality for treating well-differentiated rectal carcinoids smaller than 10 mm in diameter. Discrepancies were observed between CR-E and CR-P. The risk factors for metastasis were tumor size, increased mitotic rate, and lymphovascular invasion.
One of the most important prognostic factors in esophageal carcinoma is lymph node metastasis, and in particular, the number of affected lymph nodes, which influences long-term outcomes. The esophageal lymphatic system is connected longitudinally and transversally; thus, the pattern of lymph node metastases is very complex. Early esophageal cancer frequently exhibits skipped metastasis, and minimal surgery using sentinel node navigation cannot be performed. In Korea, most esophageal cancer cases
With unique clinicopathological features, intestinal-type MSI-H gastric cancers are associated with good prognosis and can be classified as a different subset of gastric cancers.
To the authors' knowledge, this is the first demonstration of the presence of JCV T-Ag expression in human gastric cancers. These findings suggest a possible role for this polyomavirus in gastric carcinogenesis.
The polaprezinc plus PPI treatment showed noninferiority to rebamipide plus PPI treatment in the ulcer healing rate at 4 weeks after ESD.
ESD can be considered an effective and safe alternative therapeutic and diagnostic tool for gastric lesions in cases where the forceps biopsy pathology is discrepant from the endoscopic findings. The overall final neoplastic diagnosis rate after ESD was 64.5%, and ESD should be performed for lesions with red coloration and friability.
Our results indicate that remimazolam is a safe and useful sedative for upper gastrointestinal endoscopy.
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