Yonsei University · Medicine
Professor Sung-Joo Hwang's research lab specializes in advanced drug delivery systems, focusing on enhancing the solubility, stability, and bioavailability of poorly water-soluble drugs. The lab develops innovative formulations using supercritical fluid technology, cocrystallization, and nanoparticle/liposomal systems to improve therapeutic outcomes. Key research directions include the design of sustained-release liposomal depots, cocrystal engineering, and nanoscale delivery systems for targeted cancer and ocular therapies. The lab emphasizes translational applications, particularly in oncology and ophthalmology, leveraging green chemistry and scalable processes.
Figures are computed from collected data and may differ slightly.
The study indicates that the improved aqueous solubility of the cocrystals leads to improved bioavailability of IND. Thus, the cocrystals are a viable alternative solid form that can improve the dissolution rate and bioavailability of poorly soluble drugs.
The results of this study suggest that preparation of PVP K30-sirolimus-surfactant nanoparticles using the SAS process may be a promising approach for improving the bioavailability of sirolimus.
A novel method to prepare cyclosporin A encapsulated liposomes was introduced using supercritical fluid of carbon dioxide (SCF-CO(2)) as an antisolvent. To investigate the strength of the newly developed SCF-CO(2) method compared with the modified conventional Bangham method, particle size, zeta potential, and polydispersity index (PDI) of both liposomal formulations were characterized and compared. In addition, entrapment efficiency (EE) and drug loading (DL) characteristics were analyzed by re
These results demonstrate that the novel SCF-mediated liposomal CsA promises a significant improvement in overcoming the challenges associated with the treatment of dry eyes.
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