The University of Osaka · Medicine
Professor Takaomi Hagi's research lab specializes in gastrointestinal oncology and surgical oncology, with a strong focus on improving the diagnosis and treatment of esophageal and gastric cancers. The lab investigates perioperative systemic inflammation, metastasis mechanisms, and the role of biomarkers such as circulating tumor DNA (ctDNA) and adhesion molecules in cancer progression. Key research directions include optimizing neoadjuvant chemotherapy response prediction, enhancing T-staging accuracy in gastric cancer, and exploring novel molecular diagnostics using next-generation sequencing. The lab also investigates the immunomodulatory effects of perioperative steroid therapy to prevent metastasis.
Figures are computed from collected data and may differ slightly.
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Compared to PT response, pathological LN response better predicted long-term survival in EC patients who received NAC plus curative surgery.
NGS with MB enabled comprehensive and highly sensitive detection of ctDNA in a patient with ESCC. This novel method may be useful for the clinical diagnosis of ESCC.
Perioperative systemic inflammation induced by surgical stress elevates the risk of hematogenous cancer metastasis. This study investigated the anti-metastatic effects and mechanisms of methylprednisolone (MP) administration for surgical stress. We examined the effects of MP on the expression of adhesion molecules in human vascular endothelial cells and in a murine hepatic metastasis model under lipopolysaccharide (LPS) administration, which mimics systemic inflammation induced by surgical stres
We report a case of primary hepatic gastrinoma in a patient who has been cured for 4 years postoperatively. The diagnosis was somewhat difficult due to the coexisting, multiple hyperplastic Brunner's glands of the duodenum mimicking the submucosal neuroendocrine tumors, which might have developed due to long-term hypergastrinemia.
<b>Background:</b> To improve the diagnostic accuracy of preoperative T staging in gastric cancer, the authors evaluated tumor-related factors that might affect the diagnosis. <b>Materials & methods:</b> The authors analyzed the data of cT2-4b gastric cancer patients enrolled in the prospective, multicenter JCOG1302A study. They used contrast-enhanced computed tomography to analyze the association between tumor-related factors and the diagnostic accuracy of T3-4b staging for gastric cancer. <b>R
Intraoperative CS administration mitigated postoperative CRP elevation but did not result in significantly improved survival in patients with cStage II-III gastric cancer. The study is registered with UMIN-CTR, number UMIN000024465.
Cancer selective apoptosis remains a therapeutic challenge and off-target toxicity has limited enthusiasm for this target clinically. Sigma-2 ligands (S2) have been shown to enhance the cancer selectivity of small molecule drug candidates by improving internalization. Here, we report the synthesis of a novel drug conjugate, which was created by linking a clinically underperforming SMAC mimetic (second mitochondria-derived activator of caspases; LCL161), an inhibitor (antagonist) of inhibitor of
Both ITR-PT and ITR-LN are promising predictors of survival in patients with ESCC who underwent NAC-DCF plus surgery. ITR-PT may be a stronger prognostic factor than ITR-LN.
Background: Microsatellite instability (MSI), mainly caused by dysfunction of mutL homolog 1 (MLH1), was classified as one of distinctive molecular subtype of gastric cancer. MSI was also reported to be associated with high PD-L1 expression and high Immunoscore (IS), a density analysis of tumor-infiltrating lymphocytes. This study aimed to investigate the association between MLH1, PD-L1 expression, and IS and chemosensitivity and prognosis in gastric cancer. Methods: A total of 271 patients who
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