The University of Osaka · Medicine
Professor Takayuki Hamano's research lab focuses on the pathophysiology of vascular calcification in chronic kidney disease (CKD), with a particular emphasis on the role of fetuin-A and its interaction with mineral metabolism. The lab investigates novel biomarkers such as the fetuin-mineral complex (FMC), which includes fetuin-A, fibrinogen, fibronectin-1, and calcium, to better understand systemic calcification processes. Using advanced techniques like centrifugation and immunoassays, the lab aims to clarify the discrepancy between conventional ELISA measurements and actual biological activity of fetuin-A in CKD and diabetic patients. Their work bridges clinical nephrology and molecular biology to improve early detection and management of vascular calcification.
Figures are computed from collected data and may differ slightly.
Fetuin-A is an important inhibitor of extraosseous calcification, but some of the studies that used ELISAs did not identify a significant relationship between serum fetuin-A levels and vascular calcification in patients with chronic kidney disease (CKD). Here, we used centrifugation to separate a fetuin-mineral complex (FMC) composed of fetuin-A, fibrinogen, fibronectin-1, and calcium from the serum of hemodialysis patients. In addition, we analyzed serum fetuin-A levels of 73 patients with diab
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