Kyoto University · Chemistry
Professor Takuya Kubo's research lab specializes in the development of advanced functional materials for biomedical and analytical applications, with a focus on stimuli-responsive drug delivery systems, molecularly imprinted polymers (MIPs) for selective recognition of biomolecules, and novel surface modification techniques for enhanced immobilization and separation. The lab pioneers innovative approaches using magnetic nanoparticles, C60-fullerene modified materials, and photocoupling agents to enable precise control over molecular interactions and transport. Key research directions include smart drug delivery, protein separation, and high-efficiency surface functionalization for nanomaterials and analytical devices.
Figures are computed from collected data and may differ slightly.
A new stimulus-responsive drug delivery system using Fe<sub>3</sub>O<sub>4</sub> nanoparticles coated with molecularly imprinted polymer (MIP) is reported. Magnetic thermal seeds (MTS) with their size controlled between 10 and 20 nm that could generate heat under an alternate current (AC) magnetic field were modified with a thermal-responsive MIP by grafting polymerization for effective release of an anticancer drug, methotrexate (MTX). The MIP-coated MTS showed the superparamagnetic property as
We report molecularly imprinted polymers (MIPs) for selective adsorption of proteins using a poly(ethylene glycol) (PEG)-based cross-linker with ionic monomers. To clarify the utility of the concept for preparation of the imprinted polymers using a PEG-based cross-linker, we employed lysozyme or cytochrome c as a template molecule. A few sulfonic functional monomers including sodium allylsulfonate, 2-acrylamido-2-methylpropanesulfonic acid, and sodium p-styrenesulfonate were utilized. After opti
A highly efficient photocoupling agent, based on perfluorophenylazide (PFPA)-conjugated polyallylamine (PAAm), was developed for the efficient immobilization of polymers, nanoparticles, graphene, and small molecules. The conjugate, PAAm-PFPA, was synthesized, and the percentage of the photoactive moiety, PFPA, can be controlled by the ratio of the two components in the synthesis. By treating epoxy-functionalized wafers with PAAm-PFPA, photoactive surfaces were generated. Compared with the PFPA s
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