Kyoto University · Medicine
Professor Tomoki Aoyama's research lab focuses on molecular mechanisms underlying tissue-specific gene regulation, particularly in mesenchymal stem cells and non-cartilaginous tissues. The lab investigates epigenetic regulation—especially DNA methylation—of key genes like chondromodulin-I (ChM-I) and their roles in cell differentiation and disease. A significant part of the research also explores the clinical implications of chronic low back pain in healthcare workers, linking musculoskeletal health with mental health and work productivity. The lab integrates molecular biology with translational research to uncover mechanisms of gene expression and their impact on human health and disease.
Figures are computed from collected data and may differ slightly.
It became obvious that Chronic LBP in nurses was significantly related to time management, mental-interpersonal relationship, and output. The importance of preventing a decline in work productivity by taking precautions to prevent chronic LBP and depression was suggested.
Elucidating the regulatory mechanism for tissue-specific gene expression is key to understanding the differentiation process. The chondromodulin-I gene (ChM-I) is a cartilage-specific gene, the expression of which is regulated by the transcription factor, Sp3. The binding of Sp3 to the core-promoter region is regulated by the methylation status of the Sp3-binding motif as we reported previously. In this study, we have investigated the molecular mechanisms of the down-regulation of ChM-I expressi
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