The University of Osaka · Medicine
Professor Tsuyoshi Takahashi's research lab focuses on immunology and neurodevelopmental biology, with a central emphasis on innate-like T cells, particularly invariant natural killer T (iNKT) cells, and their roles in immune regulation and homeostasis. The lab investigates the development, function, and heterogeneity of human and mouse iNKT cells, including novel subsets such as CD8+ iNKT cells, and explores their potential in immunotherapy. Additionally, the lab contributes to understanding the mechanisms of neocortical neurogenesis, particularly the dynamics of neuronal production in the embryonic ventricular zone. These interdisciplinary studies bridge immunology and developmental neuroscience, aiming to uncover fundamental principles of cell fate decisions and immune system regulation.
Figures are computed from collected data and may differ slightly.
Human Valpha24(+) NKT cells constitute a counterpart of mouse Valpha14(+) NKT cells, both of which use an invariant TCR-alpha chain. The human Valpha24(+) NKT cells as well as mouse Valpha14(+) NKT cells are activated by glycolipids in a CD1d-restricted manner and produce many immunomodulatory cytokines, possibly affecting the immune balance. In mice, it has been considered from extensive investigations that Valpha14(+)CD8(+) NKT cells that express invariant TCR do not exist. Here we introduce h
A subset of T cells in human peripheral blood expresses CD161 (NKR-P1A) receptors that are primarily associated with NK cells. In the current study we isolated blood T cell subsets according to the expression of CD161 and examined their contents of naive, central memory, and effector memory cells and their capacities for proliferation, cytokine secretion, and natural cytolysis. We found that CD4+CD161- and CD8+CD161- subsets contained predominantly naive T cells that secreted high levels of IL-2
Neocortical neuronogenesis occurs in the pseudostratified ventricular epithelium (PVE) which forms the margin of the ventricular system of the embryonic cerebral wall. We have determined that in mouse the neuronogenetic interval continues 6 days and is divisible into 11 integer cycles. The fraction of daughter cells which leaves the cycle (Q) following a curvilinear path from 0 to 1.0 over the neuronogenetic interval. Q reaches 0.5 in the course of cell cycle 8 at which point the number of daugh
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