Seoul National University · Engineering
Professor Yong Sung Park's research lab specializes in biomedical and biophysical sciences, focusing on vaccine development against bacterial pathogens such as Bacillus anthracis using novel DNA vaccine platforms, and investigating fungal iron acquisition systems as potential virulence factors in opportunistic pathogens like Aspergillus fumigatus and Fusarium graminearum. The lab also explores the complex rheological behavior of soft yield-stress fluids, particularly in oscillatory and wave-induced flows, using advanced experimental techniques like PIV and theoretical modeling. These interdisciplinary efforts span molecular immunology, fungal pathogenesis, and non-Newtonian fluid dynamics.
Figures are computed from collected data and may differ slightly.
The generation of protective humoral immune responses against the receptor-binding domain (domain IV) of protective antigen [PA(dIV)] of Bacillus anthracis represents a plausible approach against anthrax toxin. In the current study, we have developed a naked DNA vaccine encoding calreticulin (CRT) linked to PA(dIV) of Bacillus anthracis [CRT/PA(dIV)]. We transfected a human embryonic kidney cell line (HEK 293) with CRT/PA(dIV) DNA and performed Western blotting and confocal microscopy analysis.
Percutaneous extrahepatic biliary stone removal by balloon sphincteroplasty and subsequent stone pushing with occlusion balloon is an effective, safe, and technically feasible procedure which can be used as an alternative method in patients when endoscopic extrahepatic biliary stone removal was not successful.
Oscillatory pipe flows of aqueous Carbopol solutions are investigated both experimentally and analytically. Using the PIV technique, the velocity profiles are measured and compared with the numerical solutions based on an elasto-viscoplastic rheological model, in which an elastic spring is serially connected to a regularized Bingham viscoplastic model. The rheological parameters, such as shear modulus of elasticity, yield stress and viscosity, are estimated from steady-shear measurements. Good a
Aspergillus fumigatus is an opportunistic fungal pathogen for immunocompromised patients, and genes involved in siderophore metabolism have been identified as virulence factors. Recently, we identified the membrane transporters sit1 and sit2, which are putative virulence factors of A. fumigatus; sit1 and sit2 are homologous to yeast Sit1, and sit1 and sit2 gene expression was up-regulated after iron depletion. When expressed heterologously in Saccharomyces cerevisiae, sit1 and sit2 were localize
Liu & Chan ( J. Fluid Mech. vol. 579, 2007, p. 467, hereinafter referred to as LC) derived analytical solutions for the interactions between shallow water waves and a viscous fluid seabed. In this paper we present a set of new experimental data on the solitary-wave-induced flows in a viscous muddy seabed so as to validate LC's theory and the approximations employed. In the experiments a clear silicone fluid was used as the viscous mud and particle image velocimetry was employed to measure th
FgFtr1 and FgFtr2 are putative iron permeases, and FgFet1 and FgFet2 are putative ferroxidases of Fusarium graminearum. They have high homologies with iron permease ScFtr1 and ferroxidase ScFet3 of Saccharomyces cerevisiae at the amino acid level. The genes encoding iron permease and ferroxidase were localized to the same chromosome in the manner of FgFtr1/FgFet1 and FgFtr2/FgFet2. The GFP (green fluorescent protein)-fused versions of FgFtr1 and FgFtr2 showed normal functions when compared with
This study was conducted to examine the relationship between the peroxisome proliferator-associated receptor-γ (PPARγ) and MUC1 mucin, two anti-inflammatory molecules expressed in the airways. Treatment of A549 lung epithelial cells or primary mouse tracheal surface epithelial (MTSE) cells with phorbol 12-myristate 13-acetate (PMA) increased the levels of tumor necrosis factor (TNF)-α in cell culture media compared with cells treated with vehicle alone. Overexpression of MUC1 in A549 cells decre
MUC1 is a membrane-tethered mucin expressed on the apical surface of epithelial cells. Our previous report (Guang W, Ding H, Czinn SJ, Kim KC, Blanchard TG, Lillehoj EP. J Biol Chem 285: 20547-20557, 2010) demonstrated that expression of MUC1 in AGS gastric epithelial cells limits Helicobacter pylori infection and reduces bacterial-driven IL-8 production. In this study, we identified the peroxisome proliferator-associated receptor-γ (PPARγ) upstream of MUC1 in the anti-inflammatory pathway suppr
Abstract In this paper we present a set of wave flume experiments for a solitary wave reflecting off a vertical wall. A particle tracking velocimetry (PTV) technique is used to measure free-surface velocity and the velocity field in the vicinity of the moving contact line. We observe that the free surface undergoes the so-called rolling motion as the contact line moves up and down the vertical wall, and fluid particles on the free surface almost always flow toward the wall except at the end of t
Motivated by recent field observations of tsunamis, a new wave maker, namely bottom-tilting wave maker, has been designed and investigated in order to generate very long waves in the laboratory. Theoretical results from the linear wave theory and the numerical modeling based on the weakly nonlinear and weakly dispersive wave theory show good agreement with the measurements. Using both theoretical and experimental results, the relation between the bottom motion and the resulting waves have been i
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