Yong‐beom Lim

Supramolecular nanostructures covered with bioactive functional molecules have been actively explored as promising materials in the field of biotechnology. Recent advances in nano-sized chemistry have made it possible to fabricate various kinds of nanostructures with tailor-made nanostructural properties. This, combined with appropriate bioactive functionalization, has led to the successful utilization of supramolecular nanostructures in diverse biomaterials applications. This tutorial review de

The success of gene therapy is largely dependent on the delivery vector system. Efficient transfection and nontoxicity are two of the most important requirements of an ideal gene delivery vector. To generate both an efficient and nontoxic vector, we rationally constructed polymeric vectors to have simultaneous multiple functions, i.e., controlled degradation, an endosome disruptive function, and positive charges. Remarkably, the transfection efficiency of network poly(amino ester) (n-PAE) synthe

A self-destroying, biodegradable, and polycationic polyester, poly(trans-4-hydroxy-l-proline ester) (PHP ester), was synthesized, and the interaction of the polymer with polyanion DNA was investigated. Degradation of the polymer in aqueous solution was investigated by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) and by measuring the pH change as carboxylic acids are formed as products of the degradation of the polymer backbone ester bond. It was sho

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTDevelopment of a Safe Gene Delivery System Using Biodegradable Polymer, Poly[α-(4-aminobutyl)-l-glycolic acid]Yong-beom Lim, Chang-hwan Kim, Kwan Kim, Sung Wan Kim, and Jong-sang ParkView Author Information School of Chemistry & Molecular Engineering Seoul National University, Seoul 151-742, Korea Center for Controlled Chemical Delivery (CCCD) University of Utah, Salt Lake City, Utah 84112 Cite this: J. Am. Chem. Soc. 2000, 122, 27, 6524–6525Publ

A ternary complex of PPI-DAB dendrimer [(1,4-diaminobutane); Gen = N; dendri-poly(propyleneimine); -[NHC(=O)CH(2)NH(2)(+)(CH(2))(4)NH(3)(+)](z)()], DNA, and cucurbituril (CB) was evaluated as an example of a totally self-assembled gene delivery carrier. The complex was formed in a noncovalent way in which DNA interacts with PPI-DAB electrostatistically and CB with PPI-DAB through multiple noncovalent interactions. Dynamic light scattering data indicated that the diameter and size distributions o

Past decades have witnessed rapidly growing interest in nanometer-sized structures, which have great potential to be used in a variety of applications, such as electronics, sensors, coatings, and biomaterials. Supramolecular chemistry in particular has been actively applied to the development of such materials. Nanostructures can readily be accessed using bottom-up supramolecular approaches as they are composed of small molecules (supramolecular building blocks) requiring fewer steps to synthesi

Wrap it up: Nanoribbons coated with cell-penetrating peptides (CPPs) allowed the encapsulation of hydrophobic guest molecules. The nanoassembly internalized into mammalian cells with high efficiency and showed selective intracellular compartmentalization owing to its sensitivity to the solution environment. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2007/z604576_s.pdf or from the author. Please note: The publisher is not respons

Therapeutic viruses: A filament-shaped artificial virus is formed by using a preorganized supramolecular nanoribbon as a template. The artificial virus (see picture), which is composed of the nanoribbon, small interfering RNAs (blue, double-helix shape), and hydrophobic guests (red), is highly efficient in delivering genes and drugs to the inside of cells. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2008/z800266_s.pdf or from the

Protein roll call: Peptide-based building blocks, in which both an alpha-helix-forming segment and a beta-sheet segment are located within a single macrocyclic structure, self-assemble into alpha-helix-decorated artificial proteins. This approach provides a starting point for developing artificial proteins that can modulate alpha-helix-mediated interactions occurring in a multivalent fashion.

We demonstrate here the rational design strategy to control the length of 1-dimensional beta-sheet peptide nanoassembly. We synthesized the beta-sheet peptides with attached coils and carbohydrates. We reasoned that the bulkiness of the coils affects the final length of the assembled beta-sheet peptide nanostructures because of the steric crowding effect. The nanostructure from the peptide with a small and linear coil was several micrometers long, whereas the one from the peptide with a high-vol

Materials that display multiple carbohydrate residues have gained much attention due to their potential to inhibit or modulate biological multivalent interactions. These materials can be grouped accordingly to the way they are prepared, as unimolecular or as self-assembled systems. Both systems take advantage of the fact that multivalent interactions have significantly higher binding affinity than the corresponding monovalent interactions. The self-assembled system is a more recent field of rese

The design and construction of synthetic self-assembled nanostructures is, in a large part, inspired from elaborate nanostructures in biological systems. If we look at it from another angle, the self-assembled nanostructures are excellent scaffolds for exploring and modulating biological phenomena when they are suitably functionalized with bioactive molecules. Of the many types of molecular building blocks for self-assembly, peptide-based building blocks have the advantage in that their constitu