The University of Osaka · Medicine
요코마 요시히사 교수의 연구실은 신경염증과 세로토닌 수용체 5-HT3R의 신경생물학적 기능을 중심으로 한 뇌질환의 기전을 규명하는 데 초점을 맞추고 있습니다. 특히 체내 염증 반응이 뇌에 미치는 영향과 5-HT3R 수용체의 뇌 내 정밀한 발현 패atters가 인지 및 정서 기능에 미치는 영향을 분자생물학적·형태학적 접근으로 연구하고 있습니다. 이는 신경정신질환의 새로운 치료 타겟을 모색하는 데 기여합니다.
Figures are computed from collected data and may differ slightly.
As inflammation in the brain contributes to several neurological and psychiatric diseases, the cause of neuroinflammation is being widely studied. The causes of neuroinflammation can be roughly divided into the following domains: viral infection, autoimmune disease, inflammation from peripheral organs, mental stress, metabolic disorders, and lifestyle. In particular, the effects of neuroinflammation caused by inflammation of peripheral organs have yet unclear mechanisms. Many diseases, such as g
Of the many serotonin receptors, the type 3 receptors (5-HT3R) are the only ionotropic ones, playing a key role in fast synaptic transmission and cognitive and emotional brain function through controlled neuronal excitation. To better understand the various functions of 5-HT3Rs, it is very important to know their expression pattern in the central nervous system (CNS). To date, many distributional studies have shown localized 5-HT3R expression in the brain and spinal cord. However, an accurate pa
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