The University of Osaka · Medicine
Professor Yoshinori Kadono's research lab specializes in cerebrovascular and neurological disorders, with a focus on stroke mechanisms, spinal vascular malformations, and endovascular interventions. The lab investigates the pathophysiology of central poststroke pain and the neuroplastic changes underlying it, while also advancing minimally invasive treatments such as rTMS and embolization techniques for complex vascular lesions like dural arteriovenous fistulas and chronic subdural hematomas. Their work bridges clinical neurology, interventional neuroradiology, and functional neurosurgery, emphasizing innovative, image-guided therapies for challenging neurological conditions.
Figures are computed from collected data and may differ slightly.
Central poststroke pain (CPSP) develops after a stroke around the somatosensory pathway. CPSP is hypothesized to be caused by maladaptive reorganization between various brain regions. The treatment for CPSP has not been established; however, repetitive transcranial magnetic stimulation (rTMS) to the primary motor cortex has a clinical effect. To verify the functional reorganization hypothesis for CPSP development and rTMS therapeutic mechanism, we longitudinally pursued the structural and functi
Spinal epidural arachnoid cyst (EAC) is a rare, usually asymptomatic condition of unknown origin, which typically involves the lower thoracic spine. We report a case of posttraumatic symptomatic EAC with lumbar disc herniation. A 22-year-old man experienced back pain and sciatica after a traffic accident. Neurological examination revealed a right L5 radiculopathy. Magnetic resonance imaging demonstrated a cystic lesion at the L3 to L5 level and an L4-5 disc herniation; computed tomography myelog
Endovascular therapy for acute LVO stroke is feasible even in patients with VAD support.
Organized chronic subdural hematoma (OCSDH) is a rare condition lacking standardized treatment protocols. Middle meningeal artery (MMA) embolization has recently demonstrated promising outcomes in managing chronic subdural hematoma (CSDH). We present 2 cases of OCSDH treated with endovascular embolization and minimal evacuation surgery. The first case involved an 83-year-old male with a history of left CSDH drainage, admitted urgently due to right hemiplegia and dysarthria. CT scans confirmed re
Endovascular treatment for isolated dural arteriovenous fistula (DAVF) in the middle cranial fossa (MCF) with pure cortical venous drainage poses challenges, including the absence of a safe access route for transvenous embolization (TVE) and the risk of ischemia to neuro feeding vessels and dangerous anastomosis at the sphenoid wing. Therefore, surgical treatment involving direct blockage of venous reflux via craniotomy is typically preferred. We describe the case of a 63-year-old woman presente
Perimedullary arteriovenous fistulas (PMAVFs) are rare spinal vascular lesions, particularly in pediatric patients. We present a pediatric case of a ruptured cervical PMAVF, successfully treated with endovascular embolization, along with a review of relevant literature. A 10-year-old boy with no significant medical history initially presented with neck pain and fatigue, progressing to paralysis in his upper limbs and eventually all extremities. His condition further deteriorated, leading to impa
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