The University of Tokyo · Medicine
Professor Yosuke Tsuji's research lab specializes in advanced endoscopic therapies for gastrointestinal neoplasms, with a primary focus on endoscopic submucosal dissection (ESD). The lab investigates risk factors for post-ESD complications—particularly bleeding—and develops structured training programs to enhance procedural safety and efficacy among novice endoscopists. Their work emphasizes standardized, expert-supervised training to maintain high clinical outcomes during the learning curve of ESD. The lab also contributes to improving histological assessment and long-term outcomes through en bloc resection techniques.
Figures are computed from collected data and may differ slightly.
Beginner coagulators, tumor in the antrum, and medicines were significant risk factors for post-ESD bleeding. Bleeding at the ulcer margin frequently occurred with beginner operators.
Endoscopic submucosal dissection (ESD) has become widely accepted as a standard method of treatment for superficial gastrointestinal neoplasms because it enables en block resection even for large lesions or fibrotic lesions with minimal invasiveness, and decreases the local recurrence rate. Moreover, specimens resected in an en block fashion enable accurate histological assessment. Taking these factors into consideration, ESD seems to be more advantageous than conventional endoscopic mucosal res
Our training system enabled novice operators to perform gastric ESD without a decline in clinical outcomes. Key features of this training are prior intensive learning and actual ESD during the learning period under expert supervision.
Sakaguchi, Yoshiki MD; Tsuji, Yosuke MD, PhD; Fujishiro, Mitsuhiro MD, PhD; Kataoka, Yosuke MD; Takeuchi, Chihiro MD; Yakabi, Seiichi MD; Saito, Itaru MD; Shichijo, Satoki MD, PhD; Minatsuki, Chihiro MD; Asada-Hirayama, Itsuko MD, PhD; Yamaguchi, Daisuke MD, PhD; Niimi, Keiko MD, PhD; Ono, Satoshi MD, PhD; Kodashima, Shinya MD, PhD; Yamamichi, Nobutake MD, PhD; Koike, Kazuhiko MD, PhD Author Information
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