Seoul National University · Medicine
Professor Young Bin Choy's research lab specializes in the design and development of advanced biomaterials and drug delivery systems with a focus on targeted, sustained, and localized therapeutic delivery. The lab integrates nanotechnology, polymer science, and materials engineering to create innovative medical devices such as drug-eluting sutures, mucoadhesive tablets, and theranostic implants for applications in ophthalmology, orthopedics, and post-surgical care. Key research directions include the fabrication of stimuli-responsive and biodegradable carriers for improved drug bioavailability and reduced systemic side effects, as well as the development of multifunctional materials with combined diagnostic (e.g., radiopacity) and therapeutic capabilities.
Figures are computed from collected data and may differ slightly.
Uniform gelatin microspheres (GMS) of a wet size of 100 microm in diameter were fabricated by the electric field assisted precision particle fabrication (E-PPF) method and crosslinked with different glutaraldehyde (GA) concentrations to study the effect of the crosslinking density on drug release. The drug release profiles of the crosslinked GMS were studied along with the intraparticle drug distribution and the particle degradation characteristics. Due to the concentration gradient of GA along
A surgical suture is a medical device to close the wound site of skin and organs but excessive inflammation surrounding the suture can disrupt the wound healing process. Although post-operative prescription of anti-inflammatory drugs is used to manage the inflammation, the need for local drug delivery systems has been rising because of low bioavailability and fast clearance of drugs. In this work, we proposed a new strategy for a local anti-inflammatory device by incorporating macrophage-targete
This study demonstrated that mucoadhesive microdiscs formulated in a dry tablet can achieve a prolonged residence time on the preocular surface and thus are a promising drug delivery system for ophthalmic applications.
To treat glaucoma, conventional eye drops are often prescribed. However, the eye drops have limited effectiveness as a result of low drug bioavailability due to their rapid clearance from the preocular space. To resolve this, we proposed amino-functionalized mesoporous silica (AMS) particles as delivery carriers of the glaucoma drug, brimonidine. Because of the presence of mesopores, brimonidine (BMD) could be encapsulated in the AMS with a loading amount of 41.73 μg/mg (i.e., drug loading capac
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