Yonsei University · Medicine
Professor Young-Chul Jung's research lab specializes in the neurobiological and psychological mechanisms underlying addictive behaviors and cognitive control disorders. The lab investigates how brain networks—particularly those involving the dorsal anterior cingulate cortex (dACC)—govern decision-making, impulsivity, and self-regulation in conditions such as eating disorders, Internet gaming disorder, and alcohol dependence. Using multimodal neuroimaging (fMRI, voxel-based morphometry), autonomic nervous system assessments (e.g., HRV), and behavioral paradigms, the lab explores the interplay between top-down cognitive control and bottom-up reward processing. A central focus is identifying neural and physiological biomarkers that can inform early detection and targeted interventions for behavioral and substance use disorders.
Figures are computed from collected data and may differ slightly.
Cortical areas supporting cognitive control and salience demonstrate different neural responses to visual food cues in patients with eating disorders. This top-down cognitive control, which interacts with bottom-up appetitive responses, is tightly integrated not only in task conditions but also in the resting-state. The dorsal anterior cingulate cortex (dACC) is a key node of a large-scale network that is involved in self-referential processing and cognitive control. We investigated resting-stat
Alcohol dependence is a chronic disorder that results from a variety of genetic, psychosocial, and environmental factors. Relapse prevention for alcohol dependence has traditionally involved psychosocial and psychotherapeutic interventions. Pharmacotherapy, however, in conjunction with behavioral therapy, is generating interest as another modality to prevent relapse and enhance abstinence. Naltrexone and acamprosate are at the forefront of the currently available pharmacological options. Naltrex
The aim of this study was to evaluate the effects of coating implants with hydroxyapatite (HA) by an ion beam-assisted deposition (IBAD) method and to compare them with implants prepared with sand-blasted and machined surfaces. Examination of osteoblast cultures displayed no difference in the secretion of alkaline phosphatase (ALP) between the various surfaces, but the IBAD-HA specimen showed low ALP secretion (P < .05). Removal torque tests showed that implants coated with HA by the IBAD method
Because modifying risk factors of suicide attempt is important for preventing completed suicide, clinicians should carefully evaluate and monitor the risk factors of suicide attempt.
Personal attitude toward ambiguity contributes to individual differences in decision making in uncertain situations. Operationally, these attitudes reflect the various coping strategies elected to overcome the limited information. A key brain region involved in cognitive control for performance adjustments is the dorsal anterior cingulate cortex (dACC). To test how dACC functional network connectivity would be modulated by uncertainty and differ between individuals, 24 healthy participants under
Internet gaming disorder (IGD) is a behavioral addiction involving excessive online game use despite negative psychosocial consequences. Unrestricted online gaming may lead to changes in striatal activity and the relationship between the striatum and other cortical regions. This study investigated structural and functional abnormalities involving the striatum through longitudinal follow-up magnetic resonance imaging (MRI) assessments. Eighteen young males with IGD (mean age: 23.8 ± 2.0 years) an
Smartphones provide convenience in everyday life. Smartphones, however, can elicit adverse effects when used excessively. The purpose of this study was to examine the underlying neurobiological alterations that arise from problematic smartphone use. We performed resting state seed-based functional connectivity (FC) analysis of 44 problematic smartphone users and 54 healthy controls. This analysis assessed the salience, central executive, default mode, and affective networks. Compared to controls
Restriction fragment length polymorphism analyses of swine leucocyte antigen (SLA) class I genes were performed on 70 Duroc and 38 Hampshire boars from the 1986-87 national performance tests of each breed in the USA. Few boars were inbred. Southern blotting and hybridization procedures were performed on genomic DNA, isolated from white blood cells, using PvuII endonuclease and a swine major histocompatibility complex (MHC) class I probe. Durocs had an average of 11 restriction fragments, with th
We propose the formation of an Al 2 O 3 pre-layer using a protective Si-oxide layer and an Al layer. Deposition of a thin layer of aluminum onto a Si surface covered with a thin Si-oxide layer and annealing at 800°C led to the growth of Al 2 O 3 layers on Si (111). A very smooth and uniform Al 2 O 3 (111) pre-layer film was epitaxially grown on a Si (111) substrate. The surface of the γ-Al 2 O 3 film grown on the Al 2 O 3 pre-layer was very smooth with a Z range of ∼3 nm. However, the surface gr
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