Hanyang University · Engineering
Professor Youngdo Jeong's research lab specializes in the design and application of functional nanomaterials for biomedical and catalytic applications. The lab focuses on developing nanozymes and biocatalytic systems that mimic or extend enzymatic functions in complex biological environments, with applications in cancer therapy and immunomodulation. Key research directions include stimuli-responsive drug delivery systems, particularly using self-assembled emulsions and nanoparticle-based carriers, and the rational engineering of nanomaterials to achieve precise control over catalytic activity, stability, and reusability. The lab also explores the mechanical properties of ultrathin nanoparticle monolayers, linking molecular-level interactions to macroscopic material behavior.
Figures are computed from collected data and may differ slightly.
Abstract Nanozymes mimic the function of enzymes, which drive essential intracellular chemical reactions that govern biological processes. They efficiently generate or degrade specific biomolecules that can initiate or inhibit biological processes, regulating cellular behaviors. Two approaches for utilizing nanozymes in intracellular chemistry have been reported. Biomimetic catalysis replicates the identical reactions of natural enzymes, and bioorthogonal catalysis enables chemistries inaccessib
Clinical data from diverse cancer types shows that the increased T cell infiltration in tumors correlates with improved patient prognosis. Acidic extracellular pH is a major attribute of the tumor microenvironment (TME) that promotes immune evasion and tumor progression. Therefore, antagonizing tumor acidity can be a powerful approach in cancer immunotherapy. Here, Pluronic F-127 is used as a NaHCO<sub>3</sub> releasing carrier to focally alleviate extracellular tumor acidity. In a mouse tumor m
Dithiocarbamate chemistry provides a new tool to harness multifactorial colloidal self-assembly for controlled drug delivery for cancer therapy.
Emulsions stabilized by enzyme-nanoparticle (NP) complexes were used to fabricate robust biocatalytic scaffolds after core solidification via crosslinking. These biocatalysts feature ease of formation, high retention of enzymatic activity and reusability.
A modular strategy for the solubilization and protection of hydrophobic transition metal catalysts using the hydrophobic pockets of water soluble gold nanoparticles is reported. Besides preserving original catalyst activity, this encapsulation strategy provides a protective environment for the hydrophobic catalyst and brings reusability. This system provides a versatile platform for the encapsulation of different hydrophobic transition metal catalysts, allowing a wide range of catalysis in water
The elastic modulus of an ultrathin nanoparticle (NP) monolayer film is tuned by modulating the binding strength between the NPs on a molecular level. NP monolayer films constructed by crosslinking NPs of different binding affinities are fabricated at oil/water interfaces. By inducing buckling patterns on these films, the correlation between the binding affinity of the NPs and the elastic modulus is investigated.
The binding conditions and time-dependent phase transition of self-assembled monolayers (SAMs) formed by thioacetyl-terminated tolane molecules on Au(111) were examined by X-ray photoelectron spectroscopy (XPS) and scanning tunneling microscopy (STM). XPS measurements revealed that two S 2p 3/2 XPS peaks of the tolanethioacetate (TTA) SAMs on Au(111) were observed at 162 eV (bound sulfur) and 163.4 eV (unbound sulfur). On the other hand, an additional strong S 2p 3/2 XPS peak for the SAMs of tol
Using renewable photocatalysts for pollutant degradation represents a promising approach to addressing environmental water challenges by harnessing solar energy without additional energy consumption. However, for the practical use of photocatalysts, it is necessary to improve catalyst efficiency, considering cost and biocompatibility. In this study, we developed a new superabsorbent photocatalyst for the degradation of organic dyes in water. Our photocatalyst comprises halloysite nanotubes (HNTs
Photocatalysis driven by natural sunlight is an attractive approach to removing pollutants from wastewater. Although TiO<sub>2</sub>-based photocatalysts using various support nano-materials with high catalytic activity and reusability have been developed for purifying wastewater, the centrifugal separation methods used for the nanocatalysts limit their use for treating large amounts of water. Here, we prepared a TiO<sub>2</sub> nano-catalyst supported on a halloysite nanotube (HNT)-encapsulated
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