Sungkyunkwan University · Materials Science
Professor Yu Seok Youn's research lab specializes in the design and application of advanced nanomaterials for targeted drug delivery and cancer therapy. The lab focuses on bioinspired nanotherapeutics, particularly using viral and protein-based platforms to enhance tumor targeting and blood-brain barrier penetration. Key research directions include stimuli-responsive nanocarriers, ferroptosis-inducing systems, and inhalable or injectable nanoparticle formulations for improved therapeutic efficacy and reduced systemic toxicity. The lab integrates materials science, nanomedicine, and molecular oncology to develop innovative solutions for challenging cancers such as triple-negative breast cancer and brain tumors.
Figures are computed from collected data and may differ slightly.
Rabies virus-inspired silica-coated gold nanorods are fabricated by mimicking size, shape, surface glycoprotein property and in vivo behavior of the rabies virus. These nanorods not only resemble the appearance of the actual rabies virus but also travel into the brain through the neuronal pathway bypassing the blood-brain barrier, and moreover respond to near-infrared laser (808 nm) irradiation, emit heat, and effectively suppress brain tumors.
Albumin nanoparticles are considered to be an effective way to load water-insoluble anticancer drugs and target tumors via the gp60-mediated pathway. Herein, we fabricated an albumin nanoparticle formulation for co-loading paclitaxel (PTX) and curcumin (CCM), both of which have prominent anticancer efficacy, via nanoparticle albumin-bound (NabTM) technology using high-pressure homogenization. The PTX/CCM co-bound albumin nanoparticles (PTX/CCM Alb-NPs) had a slightly greater particle size of ~25
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