The University of Tokyo · Medicine
Professor Yuta Yamada's research lab focuses on urological oncology and surgical outcomes, with a primary emphasis on the molecular mechanisms of cancer progression and the clinical implications of specific biomarkers such as TRIM44 in genitourinary malignancies, including testicular germ cell tumors and renal cell carcinoma. The lab also investigates surgical outcomes following robot-assisted prostatectomy, particularly factors influencing urinary incontinence recovery and postoperative complications in elderly patients. Through integrative approaches combining clinical pathology, molecular biology, and finite element analysis, the lab explores both biological drivers of cancer and biomechanical factors in surgical implants and structural materials.
Figures are computed from collected data and may differ slightly.
Tripartite motif 44 (TRIM44) is one of the TRIM family proteins that are involved in ubiquitination and degradation of target proteins by modulating E3 ubiquitin ligases. TRIM44 overexpression has been observed in various cancers. However, its association with testicular germ cell tumor (TGCT) is unknown. We aimed to investigate the clinical significance of TRIM44 and its function in TGCT. High expression of TRIM44 was significantly associated with α feto-protein levels, clinical stage, nonsemin
Most of the IH occurred within the first 2 years with a rate of 14%. Incidence of IH after RARP was significantly associated with surgical experience and incontinence outcomes.
The present study showed that the oncologic and surgical outcomes in the elderly group were similar to those in the younger population. However, the duration of hospitalization seemed to be longer in older patients (age ≥ 75 years), despite similar complication rates.
TRIM44 has oncogenic roles in various cancers. However, TRIM44 expression and its function in renal cell carcinoma (RCC) are still unknown. Here in this study, we investigated the clinical significance of TRIM44 and its biological function in RCC. TRIM44 overexpression was significantly associated with clinical M stage, histologic type (clear cell) and presence of lymphatic invasion (P = .047, P = .005, and P = .028, respectively). Moreover, TRIM44 overexpression was significantly associated wit
The presence of baseline overactive bladder seems to represent an independent negative predictor for recovery of continence at 12 months after robot-assisted radical prostatectomy.
This study investigated the effects of cracks along rebars in reinforced concrete (RC) beams with multiple holes inside the shear spans mainly based on nonlinear finite element (FE) analyses. The analytical parameters were the hole positions that increased the shear strengths of RC beams in static loading experiments, the crack positions, and the widths. As a result of the analyses, for beams with holes arranged from near the loading points toward the positions of tensile rebars at the mid-shear
A case of tubulovillous adenoma arising in an augmented bladder is described. Ureteroileal substitution and ileocystoplasty was performed when the patient was 18 years old. She noticed gross hematuria 44 years after the surgery. Cystoscopy revealed a non-papillary multiple tumor at the site of ileovesical anastomosis and transurethral resection biopsy was performed. Histopathological examination revealed a tubulovillous adenoma. A tubulovillous adenoma developing at the augmented bladder is rare
Increased CD66b + TIN was significantly associated with presence of metastasis, S stage, and nonseminomatous germ cell tumor diagnosis. It was also an independent prognostic factor of overall survival in patients with TGCT.
Robot-assisted radical prostatectomy (RARP) has now become the gold standard treatment for localized prostate cancer. There are multiple elements in decision making for the treatment of prostate cancer. One of the important elements is life expectancy, which the current guidelines recommend as an indicator for choosing treatment options. However, determination of life expectancy can be complicated and difficult in some cases. In addition, surgical tolerability is also an important issue. Since f
Abstract: Lymphoepithelial‐like carcinoma of the renal pelvis is an extremely rare entity. Only four cases involving the renal pelvis have been previously reported. We report the fifth case of lymphoepithelioma‐like carcinoma of the renal pelvis.
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