The University of Osaka · Medicine
유메우라 유타카 교수의 연구실은 감염성 쇼크 및 열충격과 같은 급성 중증 질환에서의 염증 반응과 혈관 기능 장애를 중심으로 연구를 진행하고 있습니다. 특히 세균성 패혈성 쇼크의 병원체 분포 분석과 조기 항생제 투여의 임상적 영향을 규명하며, 임상적 치료 전략 개선에 기여하고 있습니다. 또한 코로나19로 인한 응고 이상의 특수한 혈액학적 특성과 열충격 모델에서의 백혈구 조혈세포 이식의 치료 효과를 탐구하여, 중증 질환의 새로운 치료법 개발을 목표로 하고 있습니다.
Figures are computed from collected data and may differ slightly.
This study revealed the current spectrum of pathogens and its variation based on the site of infection, which is essential for empiric antimicrobial therapy against sepsis.
Therapeutic/care management, level IV.
The hematological phenotype of COVID-19-induced coagulopathy is quite different from that in typical SIC characterized by systemic hypercoagulation and suppressed fibrinolysis. Instead, local thrombus formation might be promoted in severe COVID-19.
Completion of the hour-1 bundle was associated with lower in-hospital mortality. Obtaining blood cultures and administering antibiotics within 1 hour may have been the components most contributing to decreased in-hospital mortality.
Transplantation of BMMNCs attenuated acute systemic inflammation and vascular endothelial injury, reduced organ dysfunction, and improved survival in a rat heatstroke model. These findings provide a possible therapeutic strategy against critical heatstroke.
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