东京大学、京都大学、大阪大学等日本QS前10名大学的研究室信息。
Professor Toshimasa Yamauchi's research lab focuses on the molecular mechanisms underlying insulin sensitivity, energy homeostasis, and metabolic regulation, with a particular emphasis on adipokines such as adiponectin and nuclear receptors like PPARgamma. The lab investigates how these regulators influence glucose metabolism, lipid metabolism, and insulin signaling pathways in obesity and type 2 diabetes. Using genetically modified mouse models, including transgenic and knockout strains, the lab explores the functional roles of key metabolic regulators such as IRS-1, IRS-2, and PPARgamma variants in maintaining metabolic health. Their work aims to identify novel therapeutic targets for treating metabolic disorders through modulation of adipokine signaling and nuclear receptor activity.
Professor Hiromitsu Nakauchi's research lab specializes in stem cell biology, with a focus on hematopoietic stem cells (HSCs) and their role in lifelong blood cell production. The lab pioneers techniques for the isolation and characterization of HSCs using cell surface markers such as mCD34, enabling high-purity purification and functional analysis of individual stem cells. Their work has significantly advanced the understanding of HSC self-renewal and multilineage differentiation, with implications for regenerative medicine and transplantation therapies. The lab also explores the potential of stem cells in disease modeling and gene therapy applications.
Professor Shuhei Iimura's research lab specializes in adolescent developmental psychology, with a focus on individual differences in susceptibility to environmental influences. The lab investigates how traits such as sensory-processing sensitivity and the Big Five personality dimensions interact with life transitions—particularly the high school transition—to shape socioemotional well-being. Using longitudinal and experience sampling methods, the lab explores mechanisms underlying differential adaptation, emphasizing the role of resilience, environmental sensitivity, and personality in adolescent development. Their work contributes to the understanding of vantage and vulnerability sensitivity, advancing person–environment interaction theories in youth development.
Professor Sotaro Shibayama's research lab focuses on the dynamics of scientific innovation, creativity, and knowledge transfer within academic and entrepreneurial ecosystems. The lab investigates how individual and institutional factors—such as mentorship, scientific collaboration, and entrepreneurial engagement—affect the originality, novelty, and societal impact of research. Central themes include measuring scientific originality and novelty through citation and text analysis, understanding shifts in scientific norms due to academic entrepreneurship, and examining how PhD training environments shape future academic and entrepreneurial trajectories. The lab combines bibliometric, survey, and network analysis methods to explore the interplay between scientific behavior, innovation, and knowledge dissemination.
Professor Takayoshi Suzuki's research lab specializes in the discovery and development of selective epigenetic enzyme inhibitors, with a primary focus on histone deacetylases (HDACs), lysine demethylases (KDMs), and sirtuins. The lab employs structure-based drug design, medicinal chemistry, and biochemical assays to develop novel, isozyme-selective inhibitors for cancer and neurodegenerative diseases. A key research direction involves the design of non-hydroxamate HDAC inhibitors to overcome the pharmacokinetic and toxicity limitations of classical hydroxamate-based compounds. The lab also investigates the biological roles of these enzymes using selective chemical probes, contributing to both drug discovery and functional biology.
Professor Shinichi Yachida's research lab specializes in the molecular and pathological characterization of pancreatic and gastrointestinal malignancies, with a focus on identifying genetic drivers, metastatic mechanisms, and diagnostic biomarkers in pancreatic ductal adenocarcinoma (PDAC) and neuroendocrine tumors. The lab integrates immunohistochemistry, targeted exomic sequencing, and clinical data to uncover prognostic and therapeutic insights, particularly regarding key tumor suppressor genes (e.g., DPC4, TP53, SMAD4) and signaling pathways linked to disease progression. A central theme is improving early diagnosis and differential diagnosis of metastatic cancers through molecular profiling and microbiota analysis in colorectal cancer.
Professor Jun Sasaki's research lab specializes in membrane protein biophysics and bioengineering, with a focus on light-driven ion pumps such as bacteriorhodopsin and halorhodopsin. The lab investigates the molecular mechanisms of proton and chloride ion transport, using spectroscopic techniques like Fourier transform infrared difference spectroscopy to analyze structural changes in retinal proteins. Additionally, the lab contributes to regenerative dentistry by developing scaffold-free 3D cell constructs from dental pulp stem cells and designing bioactive barrier membranes for guided tissue and bone regeneration.
Professor Yuhei Hayamizu's research lab specializes in the integration of biological molecules with two-dimensional nanomaterials and semiconductor nanostructures to develop advanced electronic and biosensing devices. The lab focuses on peptide-based nanoarchitectonics, exploring self-assembly of designed peptides on 2D materials like graphene and MoS₂ for creating stable, functional electronic networks. Another key direction involves the optical and electronic properties of quantum wires and quantum dots, particularly in achieving low-threshold lasing and understanding many-body effects such as the Mott transition. The lab also investigates biomolecular phase separation and its implications in neurodegenerative diseases, combining computational, biochemical, and cellular approaches.
Professor Osamu Takeda's research laboratory specializes in high-temperature materials processing and molten salt chemistry, with a strong focus on sustainable resource recovery and advanced materials synthesis. Key research directions include the recycling of rare earth magnets through molten fluoride flux processes, the development of novel metal production techniques such as magnesiothermic reduction for titanium, and electrochemical synthesis of protective silicide coatings on refractory metals. The lab also conducts fundamental studies on the viscosity and transport properties of complex oxide and fluoride melts, supporting the design of efficient metallurgical processes.
Professor Keiji Yasuda's research lab specializes in sonochemistry and ultrasonic engineering, focusing on the fundamental mechanisms and applications of ultrasonic cavitation, ultrasonic atomization, and ultrasonic degassing. The lab investigates how ultrasonic intensity, frequency, and reactor configuration influence chemical reaction efficiency, mass transfer, and fluid dynamics in liquid systems. Key research directions include optimizing sonochemical reactions, enhancing gas-liquid mass transfer, and developing efficient ultrasonic processing techniques for industrial and environmental applications.
Professor Taito Miura's research lab specializes in the mechanical behavior and durability of concrete materials, with a focus on fracture mechanics, crack propagation, and long-term performance under environmental degradation. The lab investigates the influence of microstructural features—such as crack geometry and hydration products—on compressive strength and stiffness reduction, particularly under sulfate attack. Advanced experimental and computational methods, including digital image correlation (DIC) and truss network modeling, are employed to simulate and analyze the evolution of damage and phase transformation in concrete. The lab's work bridges material science and structural engineering to develop predictive models for sustainable infrastructure.
Professor Ryota Tamura's research lab focuses on neurofibromatosis and glioma biology, with a central emphasis on understanding the tumor microenvironment, including angiogenesis, immune cell infiltration, and macrophage polarization. The lab investigates targeted therapies such as VEGF/VEGFR-directed immunotherapy and gene therapy using neural stem cells and retroviral vectors for treating malignant gliomas. Innovative approaches like peptide vaccines and genome editing are explored to improve treatment outcomes in NF2 and other neurological disorders.
Professor Issei Komuro's research lab focuses on cardiovascular biology and molecular mechanisms underlying heart development, cardiac repair, and disease. The lab investigates signaling pathways involved in cardiac hypertrophy, ischemia/reperfusion injury, and the role of stem cells in myocardial regeneration. Key areas include the regulation of gene expression by growth factors and mechanical stress, the function of transcription factors in cardiomyocyte differentiation, and the impact of oxidative stress and Wnt signaling on heart development and injury. The lab also explores the potential of resident cardiac progenitor cells for therapeutic applications in heart disease.
Professor Satoshi Ide's research lab specializes in earthquake source physics, with a focus on understanding the spatiotemporal characteristics of fault rupture, stress drop, and seismic energy radiation. The lab employs advanced seismic waveform inversion and finite-source modeling to investigate rupture dynamics in large subduction zone earthquakes, such as the 1995 Kobe and 2011 Tohoku-Oki events. A key research direction involves analyzing low-frequency earthquakes and tectonic tremor to elucidate the mechanics of slow slip and plate boundary deformation. The lab also emphasizes the development and application of spectral analysis techniques to correct for path and site effects in seismic energy estimation.
Professor Yuji Eso's research lab focuses on the molecular mechanisms underlying hepatocellular carcinoma (HCC) and colorectal cancer, with a central emphasis on DNA repair pathways, microsatellite instability (MSI), and tumor immune microenvironment. The lab investigates how chronic inflammation and genetic alterations, such as MSH2 deficiency and AID expression, contribute to genomic instability and tumorigenesis. A key research direction involves evaluating the predictive biomarkers and treatment response to molecular targeted therapies (e.g., lenvatinib) and immune checkpoint inhibitors (ICIs), particularly in relation to systemic factors like NLR and pharmacokinetic metrics such as 2M-DBR. The lab also explores the translational potential of MSI and tumor mutation burden (TMB) as pan-cancer biomarkers for immunotherapy response.
Professor Yuumi Nakamura's research lab focuses on the intricate interplay between the skin immune system, the skin microbiota, and inflammatory skin diseases such as atopic dermatitis (AD) and cryopyrin-associated periodic syndrome (CAPS). The lab investigates how dysregulated innate immune responses—particularly involving interleukin-1β and interleukin-17—drive chronic inflammation, with a special emphasis on the roles of resident immune cells like mast cells and keratinocytes. Using clinical samples, animal models, and genomic analyses, the lab explores microbial colonization, quorum-sensing systems in *Staphylococcus aureus*, and host-microbe interactions that contribute to disease pathogenesis and immune regulation.
Professor Dmytro Demirskyi's research lab specializes in the design, synthesis, and characterization of advanced ultra-high temperature ceramics (UHTCs) and eutectic composites using advanced consolidation techniques such as spark plasma sintering (SPS). The lab focuses on developing medium-entropy and high-entropy carbides and borides with enhanced mechanical properties, including high flexural strength and fracture toughness, for extreme environment applications. Key research directions include in situ formation of eutectic microstructures, phase stability at elevated temperatures, and tailoring microstructure through processing parameters like pressure and temperature.
Professor Minoru Ishikawa's research lab focuses on innovative strategies in drug discovery and medicinal chemistry, particularly enhancing the aqueous solubility and bioavailability of small molecule drugs through molecular design—such as disrupting planarity and symmetry or employing photoresponsive switches like azobenzene. The lab also investigates the modulation of cytochrome P450 enzymes by cyclodextrin derivatives and develops novel therapeutic approaches, including PROTACs and SNIPERs, for targeting undruggable proteins. Their work bridges chemical innovation with translational potential in treating cancer and hormone-dependent diseases.
Professor Rina Tazai's research lab specializes in strongly correlated electron systems, with a focus on exotic quantum phases in low-dimensional and geometrically frustrated materials such as kagome metals and heavy fermion systems. The lab investigates unconventional order parameters—including bond order, charge loop current, chiral current, and nematic orders—using advanced many-body techniques like functional renormalization group (fRG) and Luttinger-Ward Fermi liquid theory. Key themes include the interplay between unconventional superconductivity, multipole order, and topological electronic states, particularly in systems with strong electron correlations and quantum interference effects.
Professor Md Anowar Hossain's research lab specializes in traffic flow dynamics, focusing on the development of advanced microscopic and continuum models that incorporate heterogeneous driver behavior, vehicle size effects, and backward-looking dynamics to improve traffic stability and flow efficiency. The lab also explores applications in radar systems, particularly UWB-OFDM SAR for high-resolution, jamming-resistant imaging, and investigates thermofluid dynamics in two-phase flows for refrigerant systems. These interdisciplinary efforts bridge transportation engineering, signal processing, and thermal systems.
