Yonsei University · Medicine
Eun-Kyung Kim 교수의 연구실은 초음파 영상 진단 기반의 갑상선 결절 평가와 관련된 정밀 분류 체계 개발에 주력하고 있으며, 특히 BI-RADS 분류 체계의 임상적 유용성과 전문 영상의사의 평가 정확도 향상에 초점을 맞추고 있습니다. 또한 면역염증 반응이 관여하는 류머티스성 관절염에서의 비만세포 기반 세포 기전(특히 IL-17이 유도하는 세포 사멸 저항성 및 미토콘드리아 기능 이상)에 대한 분자 생물학적 연구도 수행하고 있습니다. 최근에는 전기화학적 DNA 센서 기반의 고감도 유전자 진단 기술 개발을 통해 진단 생물학 분야로 연구 영역을 확장하고 있습니다.
Figures are computed from collected data and may differ slightly.
Considering the high level of sensitivity of our proposed sonographic classification, fine-needle aspiration biopsy should be performed on thyroid nodules classified as positive, regardless of palpability.
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Experienced radiologists showed more than a moderate degree of agreement in US assessment of thyroid nodules, and their final assessments were highly accurate.
Fibroblast-like synoviocytes (FLSs) are a major cell population of the pannus that invades cartilage and bone in rheumatoid arthritis (RA). FLS resistance to apoptosis is a major characteristic of RA. The aims of this study were to investigate the effects of interleukin-17 (IL-17) and IL-17-producing T helper (Th17) cells on resistance to apoptosis in FLSs from RA patients (RA FLSs) and their roles in mitochondrial dysfunction and autophagy. Mitochondrial function was assessed in RA FLSs and FLS
As with mammography, placing sonographic lesions into BI-RADS categories is useful for predicting the presence of malignancy.
We have developed a sandwich-type enzyme-linked DNA sensor as a new electrochemical method to detect DNA hybridization. A partially ferrocenyl-tethered poly(amidoamine) dendrimer (Fc-D) was used as an electrocatalyst to enhance the electronic signals of DNA detection as well as a building block to immobilize capture probes. Fc-D was immobilized on a carboxylic acid-terminated self-assembled monolayer (SAM) by covalent coupling of unreacted amine in Fc-D to the acid. Thiolated capture probe was a
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