Kyoto University · Medicine
Professor H. Matsuo's research lab focuses on molecular endocrinology and hematopoietic stem cell regulation, with a strong emphasis on the structure and function of pituitary hormones such as LH and FSH-releasing hormone. The lab also investigates transcriptional regulators like EVI1 and CEBPA in pediatric acute myeloid leukemia (AML), exploring their roles in leukemogenesis and clinical outcomes. Recent work integrates machine learning with clinical data to predict disease relapse in rheumatoid arthritis, reflecting a translational approach combining molecular biology with biomedical informatics. The lab's research spans from basic hormone structure to clinical applications in hematological malignancies and autoimmune diseases.
Figures are computed from collected data and may differ slightly.
No AccessJournal of Urology1 Feb 2002Structure of the porcine LH-and FSH-releasing Hormone.I. The proposed amino acid sequence0110 0 H. Matsuo, Y. Baba, R.M.G. Nair, A. Arimura, and A.V. Schally H. MatsuoH. Matsuo V.A. Hospital, New Orleans, LA, USA Tulane University School of Medicine, New Orleans, LA, USA More articles by this author , Y. BabaY. Baba V.A. Hospital, New Orleans, LA, USA Tulane University School of Medicine, New Orleans, LA, USA More articles by this author , R.M.G. NairR.M.G. N
The ecotropic viral integration site-1 gene (EVI1) encodes a zinc finger protein that functions as a transcriptional regulator of hematopoietic stem cell self-renewal and long-term multilineage repopulating activity. The mixed lineage leukemia gene (MLL) rearrangements [i.e. t(11q23)] occur at high frequency in pediatric acute myeloid leukemia (AML) patients with EVI1 overexpression, 3 and EVI1 is a transcriptional target of MLL oncoproteins. 4 EVI1 overexpression has been reported in up to 10%
Recent effective therapies enable most rheumatoid arthritis (RA) patients to achieve remission; however, some patients experience relapse. We aimed to predict relapse in RA patients through machine learning (ML) using data on ultrasound (US) examination and blood test. Overall, 210 patients with RA in remission at baseline were dichotomized into remission (n = 150) and relapse (n = 60) based on the disease activity at 2-year follow-up. Three ML classifiers [Logistic Regression, Random Forest, an
CCAAT/enhancer-binding protein alpha (CEBPA) mutations are a favorable prognostic factor in adult acute myeloid leukemia (AML) patients; however, few studies have examined their significance in pediatric AML patients. Here we examined the CEBPA mutation status and clinical outcomes of pediatric AML patients treated in the AML-05 study. We found that 47 (14.9%) of the 315 evaluable patients harbored mutations in CEBPA; 26 cases (8.3%) harbored a single mutation (CEBPA-single) and 21 (6.7%) harbor
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