The University of Osaka · Medicine
Professor Hiroyuki Yasuda's research lab specializes in the development of advanced catalysts and functional materials for sustainable chemical transformations. Key research directions include the design of heterogeneous and homogeneous catalysts for selective organic synthesis—such as the synthesis of propylene carbonate from CO₂ and epoxides, selective hydrogenation of nitroarenes to hydroxylamines, and cyanosilylation reactions—under mild and environmentally benign conditions. The lab also investigates novel inorganic and organometallic compounds, including silicon-containing heterocycles and high-entropy alloys, with a focus on their unique electronic and structural properties. Additionally, the group explores the relationship between catalyst composition, oxidation states, and catalytic performance, particularly in NO decomposition and CO₂ utilization.
Figures are computed from collected data and may differ slightly.
Polyfluoroalkyl phosphonium iodides, Rf3RPI (Rf = C4F9C2H4, C6F13C2H4, C8F17C2H4; R = Me, Rf), catalyzed propylene carbonate synthesis from propylene oxide and carbon dioxide under supercritical CO2 conditions, where propylene carbonate was spontaneously separated out of the supercritical CO2 phase. The Rf3RPI catalyst could be recycled with maintaining a high CO2 pressure and temperature by separating the propylene carbonate from the bottom of the reactor followed by supplying propylene oxide a
Various substituted nitroaromatics were successfully hydrogenated to the corresponding N-aryl hydroxylamines in excellent yields (up to 99%) using supported platinum catalysts such as Pt/SiO2 under a hydrogen atmosphere (1 bar) at room temperature. The key to the fast and highly selective formation of hydroxylamines is the addition of small amounts of amines such as triethylamine and dimethyl sulfoxide; amines promote the conversion of nitroaromatics, while dimethyl sulfoxide inhibits further hy
The presence of the heterogeneous mesoporous Al-MCM-41 catalyst remarkably accelerated the cyanosilylation of various aldehydes and ketones with trialkylsilyl cyanide, giving the corresponding cyanohydrin silyl ethers in quantitative yields under mild reaction conditions.
1,2,3-Trisilacyclopenta-1,4-diene 2, featuring three skeletal Si atoms in the five-membered ring, was synthesized by the thermolysis of the 1,2,3-trisilabicyclo[1.1.0]butane derivative 1 at 130 degrees C in the presence of hex-3-yne. Possessing the properties of nonconjugated cyclopentadiene, 2 readily underwent reduction with KC(8), which was followed by treatment with LiBr to form the lithium salt of 1,2,3-trisilacyclopentadienide 3(-)*[Li(+)(thf)], from which the ketone-coordinated derivative
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