Yonsei University · Medicine
Professor Ho Kyoung Hwang's research lab specializes in surgical oncology and minimally invasive pancreatic surgery, with a focus on understanding the tumor microenvironment in pancreatic ductal adenocarcinoma (PDAC). The lab investigates immune cell infiltration—particularly cytotoxic and regulatory T lymphocytes—within tumors to elucidate their impact on patient survival and treatment outcomes. Another key direction involves optimizing surgical techniques, such as splenic vessel-conserving distal pancreatectomy and anastomotic reconstruction, to improve postoperative recovery and reduce complications like delayed gastric emptying. The lab also emphasizes early intervention strategies for small, asymptomatic pancreatic cystic neoplasms to prevent disease progression.
Figures are computed from collected data and may differ slightly.
Among the subsets of tumor-infiltrating lymphocytes (TILs), activated cytotoxic T lymphocytes (granzyme B<sup>+</sup>) have an antitumor effect, while regulatory T lymphocytes [forkhead box P3 (Foxp3)<sup>+</sup>] suppress the antitumor immune response. The aim of the present study was to investigate the possible associations between TIL subsets and survival outcomes in patients with left-sided pancreatic ductal adenocarcinoma (PDAC). From January 2000 to December 2008, 30 patients who underwent
The overall DGE occurrence was not different between the two groups. However, No-Braun anastomosis was an independent risk factor for developing clinically relevant DGE.
Most patients showed intact vascular patency in conserved splenic vessels and no secondary changes in the preserved spleen after laparoscopic splenic vessel-conserving SPDP.
Before SCA causes symptoms or grows larger than 5 cm, an active surgical approach, such as minimally invasive surgery, needs to be considered.
The purpose of this study was to investigate whether splenectomy influences the tumor growth and metastatic pattern in an orthotopic syngeneic murine pancreatic cancer model. Murine pancreatic cancer cells (PAN02) were subcutaneously injected into the flanks of nude mice. A small tumor fragment (3 mm<sup>2</sup>), harvested from a subcutaneous tumor. was orthotopically implanted in the tail of the pancreas of C57/BL6 mice without splenectomy (control group, n=15) or with simultaneous splenectomy
The result suggests that enucleation for small branch duct IPMN located at the head of pancreas or uncinate process is feasible and as safe as PD, despite a high rate of minor complications.
Intraoperative transfusion should be avoided by gentle operative handling to minimize intraoperative bleeding, and the appropriate transfusion policy should be followed to increase the survival outcome.
The purpose of this study was to evaluate the time-dependent probability and risk factors of pancreatogenic diabetes mellitus (PDM) in patients who underwent minimally invasive subtotal distal pancreatectomy.Changes in glucose metabolic consequence of 34 patients (laparoscopic: 31, robotic: 3) who underwent surgery from December 2005 to December 2014 were estimated by assessing impaired fasting glucose, PDM, and PDM-free time analysis.A total of 22 patients showed glucose intolerance, including
Obese patients have an increased risk for pancreatic fistula after pancreaticoduodenectomy.
The developed nomogram had quite acceptable accuracy and clinical feasibility in the decision-making process for the management of pancreatic cancer.
SFLC showed greater technical feasibility and cost benefits in treating uncomplicated benign gallbladder disease than CLC.
Serous cystic neoplasm (SCN) of the pancreas is considered a benign tumor with almost no malignant potential. Most surgeons agree that asymptomatic SCN requires only regular observation. However, several complexities and interference with organ preservation during the operation, may develop when a huge symptomatic tumor is treated with surgery. So, the purpose of this study is to develop a potential management plan based on a literature review and by describing three recent cases of SCN of the p
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