Seoul National University · Medicine
Professor Jongheon Shin's research lab specializes in natural product chemistry, with a focus on the isolation, structural elucidation, and biological evaluation of bioactive compounds from marine and terrestrial sources. The lab investigates novel terpenoids, alkaloids, glycosides, and peptides from sponges, gorgonians, fungi, and actinomycetes, often discovering compounds with unique skeletons and significant pharmacological activities such as cytotoxicity, anti-inflammatory effects, and insulin-sensitizing properties. Their work combines advanced spectroscopic techniques, chemical degradation, and bioassay-guided fractionation to uncover structurally complex natural products with potential therapeutic applications.
Figures are computed from collected data and may differ slightly.
Four bis(indole) alkaloids of the topsentin class, including two new brominated compounds (1 and 2), have been isolated from the sponge Spongosorites genitrix collected from Jaeju Island, Korea. The structures of the novel compounds were determined by spectroscopic methods. These compounds exhibited moderate cytotoxicity against a human leukemia cell-line (K-562).
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTIsolation of New Ceramides from the Gorgonian Acabaria undulataJongheon Shin and Youngwan SeoCite this: J. Nat. Prod. 1995, 58, 6, 948–953Publication Date (Print):June 1, 1995Publication History Published online1 July 2004Published inissue 1 June 1995https://pubs.acs.org/doi/10.1021/np50120a022https://doi.org/10.1021/np50120a022research-articleACS PublicationsRequest reuse permissionsArticle Views338Altmetric-Citations60LEARN ABOUT THESE METRICSArticle
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFuscosides A-D: anti-inflammatory diterpenoid glycosides of new structural classes from the caribbean gorgonian Eunicea fuscaJongheon Shin and William FenicalCite this: J. Org. Chem. 1991, 56, 9, 3153–3158Publication Date (Print):April 1, 1991Publication History Published online1 May 2002Published inissue 1 April 1991https://pubs.acs.org/doi/10.1021/jo00009a042https://doi.org/10.1021/jo00009a042research-articleACS PublicationsRequest reuse permissionsA
A new cyclic tetrapeptide (1) was isolated from the culture broth of an actinomycete of the genus Nocardiopsis collected from the Pacific deep-sea sediment. The structure of this compound was determined to be cyclo-(L-isoleucyl-L-prolyl-L-leucyl-L-prolyl) on the basis of combined chemical and spectral methods.
Terrelumamides A (1) and B (2), two new lumazine-containing peptides, were isolated from the culture broth of the marine-derived fungus Aspergillus terreus. From the results of combined spectroscopic and chemical analyses, the structures of these compounds were determined to be linear assemblies of 1-methyllumazine-6-carboxylic acid, an amino acid residue and anthranilic acid methyl ester connected by peptide bonds. These new compounds exhibited pharmacological activity by improving insulin sens
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSuberitenones A and B: Sesterterpenoids of an unprecedented skeletal class from the Antarctic sponge Suberites sp.Jongheon Shin, Youngwan Seo, Jung-Rae Rho, Eunjoo Baek, Byoung-Mog Kwon, Tae-Sook Jeong, and Song-Hae BokCite this: J. Org. Chem. 1995, 60, 23, 7582–7588Publication Date (Print):November 1, 1995Publication History Published online1 May 2002Published inissue 1 November 1995https://pubs.acs.org/doi/10.1021/jo00128a034https://doi.org/10.1021/j
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStructures and reactivities of new dolabellane diterpenoids from the Caribbean gorgonian Eunicea laciniataJongheon Shin and William FenicalCite this: J. Org. Chem. 1991, 56, 10, 3392–3398Publication Date (Print):May 1, 1991Publication History Published online1 May 2002Published inissue 1 May 1991https://doi.org/10.1021/jo00010a039RIGHTS & PERMISSIONSArticle Views241Altmetric-Citations32LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant su
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