Keio University · Medicine
Professor Kazuhiro Matsumoto's research lab specializes in advancing medical imaging and cancer immunotherapy. The lab focuses on optimizing spectral CT imaging using photon-counting detectors to improve diagnostic image quality while reducing radiation dose, with applications in routine clinical imaging. In parallel, the lab investigates innovative gene delivery strategies—particularly liposome-mediated intravesical IL-15 gene therapy—for enhancing anti-tumor immunity in bladder cancer. These dual research directions aim to improve both diagnostic accuracy and therapeutic outcomes in oncology.
Figures are computed from collected data and may differ slightly.
VMS imaging at approximately 70 keV yielded lower image noise and higher CNR than did 120-kVp CT for a given radiation dose. VMS imaging has the potential to replace 120-kVp CT as the standard CT imaging modality, since optimal VMS imaging may be expected to yield improved image quality in a patient with standard body habitus.
Interleukin-15 (IL-15) is known to stimulate the proliferation of CD8(+) T-cells and natural killer cells, and also to help to maintain memory CD8(+) T cells, suggesting that it may be of value in cytokine treatment of bladder cancer. In this experiment, we tested the efficiency of intravesical liposomal IL-15 gene delivery and its antitumor effect in a mouse orthotopic bladder cancer model. We established an orthotopic bladder cancer model by implanting 5×10(5) MBT-2 cells into female C3H/HeN m
Open papers in the app to read, cite, and organize with AI.
