Kyung Hee University · Engineering
Professor Kyo Seon Hwang's research lab specializes in the development of advanced nanomechanical biosensors for label-free, real-time detection of biomolecular interactions. The lab focuses on micro- and nanoscale cantilever-based sensors that exploit changes in resonant frequency or surface stress upon biomolecule binding, enabling high-sensitivity detection in liquid environments. Key research directions include novel materials integration—such as PZT thin films and functionalized self-assembled monolayers—and the application of MEMS fabrication techniques to enhance device performance and portability. The lab also emphasizes quantitative modeling of surface stress to correlate mechanical responses with specific biological interactions.
Figures are computed from collected data and may differ slightly.
We report on a novel technique of resonant frequency shift measurement based on a nanomechanical cantilever with a PZT actuating layer for label-free detection of a prostate-specific antigen (PSA) in a liquid environment. The nanomechanical PZT thin film cantilever is composed of SiO(2)/Ta/Pt/PZT/Pt/SiO(2) on a SiN(x) supporting layer for simultaneous self-exciting and sensing; it was fabricated using a standard MEMS (micro electromechanical system) process. The specific binding characteristics
Recent research trends in biosensing have been geared toward developing bioanalytical devices that are label free, small in size, and portable and that can operate in a rapid manner. The performance of these devices has been dramatically improved through the advent of new materials and micro-/nanofabrication technologies. This is especially true for micro-/nanosized cantilever sensors, which undergo a change in mechanical properties upon the specific binding of biomolecules. In this review, we i
Nanomechanical microcantilevers have played a vital role in detecting biomolecular interactions. The ability of microcantilevers to detect biomolecular interactions is ascribed to the principle that the surface stress, caused by biomolecular interactions, dominates the dynamical response of the microcantilever. Here we have experimentally studied the correlation between biomolecular interactions and the dynamical response of microcantilevers. Moreover, the authors employed a mechanical beam mode
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