Hokkaido University · Medicine
Professor Masatake Matsuoka's research lab focuses on the molecular and genetic mechanisms underlying tissue repair, particularly in articular cartilage and soft tissue sarcomas. The lab investigates glycosylation pathways in cartilage regeneration and develops preclinical models—especially in C57Bl/6 mice—to dissect the biological processes governing tissue repair. Additionally, the lab explores clinical risk factors for metastasis in sarcomas and evaluates the integration of artificial intelligence, such as ChatGPT, in aligning with clinical guidelines for sarcoma treatment.
Figures are computed from collected data and may differ slightly.
To analyze the genetic and biomolecular mechanisms underlying cartilage repair, an optimized mouse model of osteochondral repair is required. Although several models of articular cartilage injury in mice have recently been established, the articular surface in adult C57Bl/6 mice heals poorly. Since C57Bl/6 mice are the most popular strain of genetically manipulated mice, an articular cartilage repair model using C57Bl/6 mice would be helpful for analysis of the mechanisms of cartilage repair. Th
Elucidation of the healing mechanisms in damaged tissues is a critical step for establishing breakthroughs in tissue engineering. Articular cartilage is clinically one of the most successful tissues to be repaired with regenerative medicine because of its homogeneous extracellular matrix and few cell types. However, we only poorly understand cartilage repair mechanisms, and hence, regenerated cartilage remains inferior to the native tissues. Here, we show that glycosylation is an important proce
Patients with STS need to be followed-up by frequent clinical assessments if they have a smoking history.
Risk factors for liver metastasis were deep location, trunk development, larger tumor size, high histological grade, and specific histological subtypes.
Our results clearly indicated that patient backgrounds differed, such as younger age and greater tendencies to affect males, develop in an extremity and show high-grade tumor in patients with FS-B. In contrast, no differences were observed in distant metastatic potential or survival.
Our study demonstrates that AI, specifically ChatGPT, can align with clinical guidelines for soft tissue sarcoma treatment. It also underscores the need for continuous refinement and cautious integration of AI in medical decision-making, particularly in the context of treatment for soft tissue sarcoma.
To the best of our knowledge, this represents the first report of correction osteotomy for varus knee deformity due to premature epiphyseal closure that occurred during treatment with isotretinoin.
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