Kyung Hee University · Medicine
Professor Sang Wook Kang's research lab specializes in molecular and translational medicine, focusing on the genetic and molecular mechanisms underlying cancer susceptibility, bone metabolism, and oxidative stress-related diseases. The lab investigates genetic polymorphisms in DNA repair and antioxidant enzymes—such as SOD2, hOGG1, and ACE—using meta-analytical approaches to clarify their roles in disease risk. Additionally, the lab explores natural compounds, like pinoresinol glucoside and TMARg, for their potential in promoting osteoblast differentiation and treating bone disorders through modulation of BMP2 and Wnt/β-catenin signaling pathways. The research integrates molecular biology, cell culture, and bioinformatics to identify therapeutic targets and phytomedicines for cancer and skeletal diseases.
Figures are computed from collected data and may differ slightly.
In this study, we show for the first time that potassium fluoride (KF) can be utilized as a carrier for facilitated CO2 transport. A polymer electrolyte membrane was prepared by incorporating KF through coordinate covalent bonding with the amide groups of poly(vinylpyrrolidone) (PVP). The resulting PVP/KF electrolyte membrane showed enhanced CO2 separation performance compared with neat PVP. The selectivity ratio CO2/N2 increased to 4.1 with a CO2 permeance of 28 GPU. This enhanced separation pe
With increasing technological demand for portable electronic and photovoltaic devices, it has become critical to ensure the electrical and mechano-electric reliability of electrodes in such devices. However, the limited flexibility and high processing costs of traditional electrodes based on indium tin oxide undermine their application in flexible devices. Among various alternative materials for flexible electrodes, such as metallic/carbon nanowires or meshes, silver nanowire (Ag NW) networks ar
CD137 (4-1BB) is a T-cell costimulatory molecule, and agonstic CD137 antibodies are currently being evaluated in the clinic as cancer immunotherapy. Recently, it was found that CD137<sup>-/-</sup> mice or mice injected with agonistic anti-CD137 antibodies exhibit heightened antitumor responses, contrary to expectations based on other knowledge of CD137 function. Here, we report findings related to reverse signaling by CD137 ligand (CD137L) in antigen-presenting dendritic cells (DC) in tumors tha
Superoxide dismutase, one of the antioxidant enzymes, plays an important role in defense against reactive oxygen species. Many previous studies reported the association between SOD2 polymorphism and the cancer risk but the results were divergent. Therefore, we performed a meta-analysis to investigate the association between SOD2 polymorphism and the cancer susceptibility. We searched in Electronic database including Pubmed, Embase, google of scholar, and Korean Studies Information Service System
A theoretical model is made to investigate the coupling effects of the trim and air gap on the frequency response characteristics of a passenger compartment. With the model, a parametric study is carried out to understand the relation between the acoustic response of the cavity and the design variables associated with the roof, trim, and air gap between the two. The validity of theoretical formulations is verified through a comparison between the theoretical results and the finite element analys
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