The University of Tokyo · Medicine
Professor Sho Kiritani's research lab specializes in translational biomedical engineering and precision oncology, focusing on the development of innovative tissue-engineered vascular grafts using biocompatible materials like silk fibroin for cardiovascular and vascular repair. The lab also pioneers the application of rapid mass spectrometry techniques—particularly PESI-MS—combined with machine learning for real-time intraoperative diagnosis of liver metastases and pancreatic tumors, enabling accurate and timely pathological assessment. A key research direction involves identifying lipid-based biomarkers for early detection and therapeutic targeting of colorectal liver metastases and intraductal papillary mucinous neoplasms.
Figures are computed from collected data and may differ slightly.
No alternative tissue-engineered vascular grafts for the abdominal venous system are reported. The present study focused on the development of new tissue-engineered vascular graft using a silk-based scaffold material for abdominal venous system replacement. A rat vein, the inferior vena cava, was replaced by a silk fibroin (SF, a biocompatible natural insoluble protein present in silk thread), tissue-engineered vascular graft (10 mm long, 3 mm diameter, n = 19, SF group). The 1 and 4 -week paten
The combination of PESI-MS and machine learning distinguished CRLM from non-cancer tissue with high accuracy. Phospholipids categorized as monounsaturated fatty acids contributed to the difference between CRLM and normal parenchyma and might also be a useful diagnostic biomarker and therapeutic target for CRLM.
PESI-MS combined with machine learning is an easy-to-use tool with the advantage of rapid on-site analysis. Here, we show the great potential of our system to diagnose the malignant conversion of IPMN, which would be a promising diagnostic tool in clinical settings.
Abstract Background: Probe electrospray ionization-mass spectrometry (PESI-MS) can rapidly visualize mass spectra of small, surgically obtained tissue samples, and is a promising novel diagnostic tool when combined with machine learning which discriminates malignant spectrum patterns from others. The present study was performed to evaluate the utility of this device for rapid diagnosis of colorectal liver metastasis (CRLM). Methods: A prospectively planned study using retrospectively obtained ti
Although HPD for widespread PhCC requires careful postoperative management, it has the potential to provide excellent long-term outcomes, and it should be considered proactively.
Administration of the selective arginine vasopressin V2 receptor antagonist tolvaptan to cirrhotic patients is controversial. There are no reports of tolvaptan use for patients with far-advanced end-stage liver disease (ESLD) and refractory ascites awaiting liver transplantation. Between 2013 and 2016, 64 patients awaiting adult-to-adult living donor liver transplantation (LDLT) were screened for enrollment. Patients with refractory ascites and on dual conventional diuretics (≥ 50 mg/day of spir
A tumor size of 3 cm was associated with surgical futility in resectable pancreatic cancer and served as a useful factor for fine stratification of long-term postoperative outcomes.
N1 (CHA) is a strong negative prognostic factor in eCCA. CHA node status may serve as a useful imaging-based marker of biological resectability.
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