Keio University · Medicine
Professor Shotaro Chubachi's research lab focuses on the complex interplay between chronic respiratory diseases, particularly chronic obstructive pulmonary disease (COPD), and their systemic comorbidities. The lab investigates the pathophysiological mechanisms linking COPD with conditions such as osteoporosis, pulmonary hypertension, lung cancer, and metabolic disorders like hyperuricemia. A key research direction involves identifying genetic and radiological risk factors—such as LRP5 polymorphisms and emphysematous or interstitial lung abnormalities—that contribute to disease progression and poor outcomes. The lab also examines the impact of viral infections, including SARS-CoV-2, on respiratory health, particularly in the context of disease severity and vaccination effects. These studies aim to improve risk stratification, early detection, and personalized management strategies for COPD patients.
Figures are computed from collected data and may differ slightly.
Abstract Background and objective Osteoporosis is an important systemic comorbidity of chronic obstructive pulmonary disease ( COPD ). However, neither its mechanisms nor its risk factors have been fully elucidated. With regard to genetic factors, low‐density lipoprotein receptor‐related protein 5 ( LRP 5 ) A 1330 V is known to be associated with osteoporosis in the general population, but the influence of this polymorphism in COPD is unknown. The aim of this study was to investigate the potenti
The severity of COPD exacerbation seemed to be temporally stable over 2 years, and even mild exacerbations adversely impacted the health-related quality of life of patients with COPD.
The presence of emphysema or interstitial abnormalities or a combination of both were independent predictors of lung cancer development in COPD patients. Furthermore, lung cancer most often developed in non-emphysematous areas or in interstitial abnormalities.
Patients hospitalized with COVID-19 with Omicron infections showed a lower incidence of critical outcomes than those with Delta infections, and COVID-19 vaccination may contribute to preventing respiratory failure.
In this study, we identified the clinical characteristics of COPD patients with PH detected by echocardiography. The presence of PH assessed by echocardiography was related to future COPD exacerbations and closely related to radiographical emphysema.
Abnormal serum uric acid levels or a history of hyperuricemia were significantly associated with COVID-19 severity in the Japanese cohort.
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