The University of Osaka · Biochemistry, Genetics and Molecular Biology
우치야마 스وم스 교수의 연구실은 바이오의약품 안정성 및 제형 개발을 핵심으로 하며, 단백질 약물의 응집 메커니즘과 고체-액체 계면에서의 상호작용을 규명하고 있습니다. 특히 편입주사(_prefillable syringe)의 소재와 실리콘 오일 런버케이션의 영향을 분석하여 약물의 안정성을 향상시키는 데 초점을 맞추고 있습니다. 또한 바이러스 벡터의 잡질 제거 및 정량 분석 기술 개발을 통해 바이오의약품의 품질 보증에도 기여하고 있습니다. 이와 더불어, 고체 분리 및 정제 공정 최적화를 위한 새로운 자기여과 필터 기술 개발도 진행 중입니다.
Figures are computed from collected data and may differ slightly.
Currently, polymer-based prefillable syringes are being promoted to the pharmaceutical market because they provide an increased break resistance relative to traditionally used glass syringes. Despite this significant advantage, the possibility that barrel material can affect the oligomeric state of the protein drug exists. The present study was designed to compare the effect of different syringe materials and silicone oil lubrication on the protein aggregation. The stability of a recombinant fus
DNA is packaged as chromatin in the interphase nucleus. During mitosis, chromatin fibers are highly condensed to form metaphase chromosomes, which ensure equal segregation of replicated chromosomal DNA into the daughter cells. Despite >1 century of research on metaphase chromosomes, information regarding the higher order structure of metaphase chromosomes is limited, and it is still not clear which proteins are involved in further folding of the chromatin fiber into metaphase chromosomes. To obt
A new type of the HGMS filter is proposed in which the slurry flows parallel to the ferromagnetic fine wires (Parallel stream type magnetic filter). In this configuration, the capturing magnetic force scarcely competes with the drag force or the gravitational force. The recovery of the filter is calculated based on the particle trajectory model. The experimental result for hematite slurry agrees well with the present theory. A preliminary result is presented on the maintenance test of the filter
During the manufacturing of recombinant adeno-associated virus vectors, it is generally difficult to purify out vectors that lack nucleic acids (empty particles, EPs), contain incomplete nucleic acids (intermediate particles, IPs) or aggregates. These impurities may cause side effects and therefore it is essential to both quantify and reduce them; however, comprehensive identification of the size distribution and components of virus vectors have been lagging. We developed multiwavelength sedimen
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