Kyushu University · Medicine
Professor Toshiharu Ninomiya's research lab focuses on the intersection of metabolic and cardiovascular diseases, with a strong emphasis on diabetes, kidney function, and cerebrovascular health. The lab investigates the long-term impact of biomarkers such as albuminuria and estimated glomerular filtration rate (eGFR) on cardiovascular and renal outcomes in diabetic populations. It also explores the complex relationships between hypertension, dementia, and lifestyle factors such as diet, particularly in aging Japanese cohorts. The research aims to identify modifiable risk factors and improve preventive strategies for chronic diseases in aging populations.
Figures are computed from collected data and may differ slightly.
There are limited data regarding whether albuminuria and reduced estimated GFR (eGFR) are separate and independent risk factors for cardiovascular and renal events among individuals with type 2 diabetes. The Action in Diabetes and Vascular disease: preterAx and diamicroN-MR Controlled Evaluation (ADVANCE) study examined the effects of routine BP lowering on adverse outcomes in type 2 diabetes. We investigated the effects of urinary albumin-to-creatinine ratio (UACR) and eGFR on the risk for card
Diabetes mellitus and cancer are diseases of epidemic proportions across the globe. These diseases are influenced by many factors, both genetic and environmental. A possible association between diabetes and cancer risk has long been speculated. Increased incidence of several cancers has been observed in diabetes patients, notably pancreatic, hepatic, colorectal, breast, urinary tract, and endometrial cancers. In contrast, a decreased incidence of prostate cancer is observed in diabetes patients,
The associations between blood pressure and dementia have been inconclusive. We followed up a total of 668 community-dwelling Japanese individuals without dementia, aged 65 to 79 years, for 17 years and examined the associations of late-life and midlife hypertension with the risk of vascular dementia and Alzheimer disease using the Cox proportional hazards model. During the follow-up, 76 subjects experienced vascular dementia and 123 developed Alzheimer disease. The age- and sex-adjusted inciden
The Mediterranean diet may protect against vascular disease. However, both the quantity and quality of the available evidence is limited and highly variable. Results must be interpreted with caution.
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