The University of Osaka · Medicine
Professor Yohei Nose's research lab specializes in gastrointestinal oncology and surgical innovation, with a strong focus on improving outcomes in upper gastrointestinal cancers such as esophageal and gastric cancer. The lab investigates predictive biomarkers—particularly in peripheral blood and tumor microenvironments—for immunotherapy response, aiming to personalize treatment strategies. Additionally, the lab explores novel surgical techniques, including endoscopic submucosal dissection (ESD) and minimally invasive approaches like FLEXLOOP and transhiatal repair, for complex gastrointestinal defects and perforations. A significant component of the lab’s work also involves understanding immune modulation by antibiotics, particularly macrolides, in poultry models, with potential translational implications for cancer immunotherapy.
Figures are computed from collected data and may differ slightly.
TLG reduction is the best predictor of prognosis. Preoperative PET-CT evaluation of both the primary tumour and lymph nodes could accurately stratify risk in OSCC patients.
While many antimicrobial agents have been reported to cause immunosuppression in animals, macrolide antibiotics enhance the immune function. Tylosin tartrate is a macrolide antibiotic approved for the control of mycoplasmosis in poultry. The purpose of this investigation was to determine the effect of tylosin on the humoral immune functions in chickens. Three days after oral tylosin tartrate administration, 4- or 8-week-old chickens were immunized intravenously with carbolic acid-killed Brucella
Abstract Background Immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment. Since clinical benefits are limited to a subset of patients, we aimed to identify peripheral blood biomarkers that predict the efficacy of the anti-programmed cell death protein 1 (PD-1) antibody (nivolumab) in patients with gastric cancer. Methods We collected peripheral blood samples from gastric cancer patients (n = 29) before and after treatment with nivolumab and investigated the relationship betwe
FLEXLOOP can be a promising option for defect closure after ESD.
Schwannomas are rarely observed in the gastrointestinal tract. A 63-year-old man was referred to our hospital with gastric submucosal tumor with central ulceration by upper gastrointestinal endoscopy. Biopsy was performed, but pathological diagnosis was not obtained. A contrast-enhanced computed tomography scan of the abdomen revealed a round mass in the lower part of the stomach and regional lymphadenopathies. A distal gastrectomy with dissection of the regional lymph nodes (D2)was performed. T
食道裂孔ヘルニア内で発症した胃穿孔に対し，緊急手術を行った1例を経験したので報告する．症例は78歳，女性．吐血を主訴に救急搬送された．上部消化管内視鏡で食道胃接合部に多発の縦走潰瘍と，CT検査で縦隔内気腫を認め，食道破裂疑いで緊急手術となった．胸水は少量で縦隔気腫が下縦隔に限定していたことから，経裂孔アプローチを選択した．上腹部正中切開を行い食道裂孔部に至ると，食道裂孔ヘルニアを認めた．ヘルニア内部で噴門部に約5cmの裂創を認め，胃管が露出していた．潰瘍穿孔部を単純閉鎖した後，食道裂孔を閉鎖し，胃底部を吻合部前壁と横隔膜脚に縫着し噴門形成を行った．経胃腸瘻を留置し，術中内視鏡で縫合部の閉鎖を確認し手術を終了した．術後8日目の造影検査で縫合不全を認めたが，ドレーン管理による瘻孔化を図り，23日目に内視鏡下の吻合部閉鎖を施行した．その後，40日目から経口摂取を開始し63日目に転院した．
A 69-year-old man was admitted for the growing anal tumor and referred to our hospital. The tumor was about 40mm in size, and by biopsy, he was diagnosed the adenocarcinoma. Based on this diagnosis, abdominoperinealresection and edge resection were performed. Histopathologicalfindings showed mucinous carcinoma originating from analgl and with pagetoid spread. Postoperative chemotherapy was not performed, but 1 year 6 months after the surgery, inguinall ymph node recurrence was found, and lymph n
A 75-year-old man was admitted with abdominal pain and taken to our hospital. CT and MRI showed a tumor measuring 60mm in diameter in the pelvic cavity. Based on the imaging findings, we suspected a schwannoma and decided to perform surgery. As the tumor was found to be benign in intraoperative frozen section diagnosis, the tumor was enucleated. Histopathological findings showed no nuclear atypia, and the patient was diagnosed with a schwannoma. He complained of paresthesia in his right leg afte
Hepatocellular carcinoma with bile duct invasion is rare, with a reported incidence of 3.4%. A 71-year-old man with hepatocellular carcinoma underwent radiofrequency ablation(RFA)(S6, S7, S8)and required readmission 22 months after the RFA for hepatocellular carcinoma recurrence detected by gadoxetic acid-enhanced magnetic resonance imaging. Enhanced abdominal computed tomography and magnetic resonance cholangiopancreatography revealed a tumor thrombus in a biliary branch and left adrenal gland
2015 International Conference on Solid State Devices and Materials,Chemical Vapor Deposition of Highly Resistive ZnO Films using Nonequilibrium N<sub>2</sub>/O<sub>2</sub> Plasma Generated near Atmospheric Pressure
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