A-Yeong Choi
Yonsei University · Medicine
About the Lab
Professor A-Yeong Choi's research lab specializes in molecular hepatology and genetic mechanisms underlying liver diseases, with a primary focus on the ATP-binding cassette transporter MDR3 (ABCB4). The lab investigates the functional consequences of disease-causing mutations in ABCB4, particularly in the context of progressive familial intrahepatic cholestasis type 3 (PFIC3), using in vitro biochemical and cellular assays. Key research directions include characterizing the transport activity and subcellular localization of mutant MDR3 proteins, elucidating pathogenic mechanisms at the molecular level, and exploring potential therapeutic targets for cholestatic liver disorders.
Research Overview
Research Output Trend
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Selected Papers
1Multidrug resistance 3 (MDR3), encoded by the ATP-binding cassette, subfamily B, member 4 gene (ABCB4), localizes to the canalicular membrane of hepatocytes and translocates phosphatidylcholine from the inner leaflet to the outer leaflet of the canalicular membrane. Progressive familial intrahepatic cholestasis type 3 (PFIC3) is a rare hepatic disease caused by genetic mutations of ABCB4. In this study, we characterized 8 ABCB4 mutations found in PFIC3 patients, using in vitro molecular assays.
Research Areas
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