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Bong-Soon Chang

Seoul National University · Medicine

About the Lab

Professor Bong-Soon Chang's research lab specializes in spinal implant biomaterials and spinal fusion surgery, focusing on developing and evaluating advanced bone graft substitutes and interbody fusion devices. The lab investigates bioactive glass-ceramics, such as CaO-SiO2-B2O3 (CS10B), for their osteoconductive properties, biodegradation behavior, and mechanical stability in spinal fusion applications. Key research directions include improving fusion outcomes through enhanced implant integration with host bone, optimizing surgical techniques for cervical spine instrumentation, and enhancing diagnostic accuracy in spinal interventions. The lab combines preclinical animal studies with clinical trials to translate biomaterial innovations into safer, more effective spinal surgery solutions.

spinal fusionglass-ceramicsbone graft substitutesinterbody fusionbiomaterials

Research Overview

Papers
338
Total Citations
6,971
Papers (5y)
38
Primary Field
Medicine

Research Output Trend

Figures are computed from collected data and may differ slightly.

Publications per year (5y)
38total
2022
2023
2024
2025
2026
Citations per year (5y)
234total
20222023202420252026

Selected Papers

15
1
Article|628 citations·2000
Osteoconduction at porous hydroxyapatite with various pore configurations
Bong‐Soon Chang, Choon‐Ki Lee, Kug-Sun Hong, Hyuk‐Joon Youn, Hyun-Seung Ryu, Sung Soo Chung, Kunwoo Park
SJR Q1Biomaterials
Biomedical EngineeringEngineering
2
Article|104 citations·2013
Asymmetry of the cross-sectional area of paravertebral and psoas muscle in patients with degenerative scoliosis
Hyoungmin Kim, Choon‐Ki Lee, Jin S. Yeom, Jae Hyup Lee, Jae Hwan Cho, Sang Ik Shin, Hui-Jong Lee, Bong‐Soon Chang
SJR Q1European Spine JournalOA
SurgeryMedicine
3
Article|83 citations·2010
Fusion Rates and Subsidence of Morselized Local Bone Grafted in Titanium Cages in Posterior Lumbar Interbody Fusion Using Quantitative Three-Dimensional Computed Tomography Scans
Jae Hyup Lee, Do-Whan Jeon, Suk-Jae Lee, Bong‐Soon Chang, Choon‐Ki Lee
SJR Q1Spine

The ratio of fused area of local bone inside cages at regions exposed to endplates was <50%, which is insufficient for physiologic load transmission. The authors recommend that additional bone should be grafted into the disc space or new bone bonding interbody spacer should be considered.

Pathology and Forensic MedicineMedicine
4
Article|81 citations·2008
Undetected Vertebral Artery Groove and Foramen Violations During C1 Lateral Mass and C2 Pedicle Screw Placement
Jin S. Yeom, Jacob M. Buchowski, Kunwoo Park, Bong‐Soon Chang, Choon‐Ki Lee, K. Daniel Riew
SJR Q1Spine

Although vertebral artery groove and foramen violations were relatively common on postoperative CT scans, none were detected intraoperatively or on postoperative radiographs. Most alarmingly, 1 vertebral artery injury was undetected intraoperatively. Since a vertebral injury can be potentially catastrophic, this study emphasizes the inherent dangers associated with placement of C1 and C2 screws and underscores the importance of careful postoperative evaluation and surgical technique when inserti

SurgeryMedicine
5
Article|67 citations·2007
Scoliosis associated with syringomyelia: analysis of MRI and curve progression
Jin S. Yeom, Choon‐Ki Lee, Kunwoo Park, Jae Hyup Lee, Dong‐Ho Lee, Kyu‐Chang Wang, Bong‐Soon Chang
SJR Q1European Spine JournalOA
Public Health, Environmental and Occupational HealthMedicine
6
Article|52 citations·2016
Comparison of fusion rate and clinical results between CaO-SiO2-P2O5-B2O3 bioactive glass ceramics spacer with titanium cages in posterior lumbar interbody fusion
Jae Hyup Lee, Chang-Bae Kong, Jae Jun Yang, Hee-Jong Shim, Ki Hyoung Koo, Jeehyoung Kim, Choon‐Ki Lee, Bong‐Soon Chang
SJR Q1The Spine JournalOA

BACKGROUND CONTEXT: glass ceramics spacer generates chemical bonding to adjacent bones with high mechanical stability to produce a union with the end plate, and ultimately stability. PURPOSE: glass ceramics with a titanium cage that is widely used for posterior lumbar interbody fusion (PLIF) surgery in the clinical field. STUDY DESIGN/SETTING: This is a prospective, stratified randomized, multicenter, single-blinded, comparator-controlled non-inferiority trial. PATIENT SAMPLE: The present study

Pathology and Forensic MedicineMedicine
7
Article|51 citations·2008
Value of Diagnostic Lumbar Selective Nerve Root Block: A Prospective Controlled Study
Jin S. Yeom, Joon Woo Lee, K.-W. Park, Bong‐Soon Chang, Choon‐Ki Lee, Jacob M. Buchowski, K. Daniel Riew
SJR Q1American Journal of NeuroradiologyOA

The accuracy of diagnostic lumbar selective nerve root blocks is only moderate. To improve the accuracy, great care should be taken to avoid inadequate blocks and overflow, and to precisely interpret spot radiographs.

Pathology and Forensic MedicineMedicine
8
Article|47 citations·2004
Evaluation of the biological response of wear debris
Bong‐Soon Chang, Phillip Rand Brown, Ann N. Sieber, Antonio Valdevit, Kei Tateno, John P. Kostuik
SJR Q1The Spine Journal
Pathology and Forensic MedicineMedicine
9
Article|39 citations·2006
In vivo study of novel biodegradable and osteoconductive CaO‐SiO2‐B2O3 glass‐ceramics
Jae Hyup Lee, Choon‐Ki Lee, Bong‐Soon Chang, Hyun‐Seung Ryu, Jun‐Hyuk Seo, Kug Sun Hong, Hwan Kim
SJR Q1Journal of Biomedical Materials Research Part A

To evaluate the possibility of novel CaO-SiO2-B2O3 glass-ceramics (CS10B) as a new bone replacement material, we compared the biodegradation and osteoconduction properties of CS10B, hydroxyapatite (HA), and tricalcium phosphate (TCP). Porous CS10B implants were prepared by the polymer sponge method. L5-6 single-level posterolateral spinal fusions were performed on 30 New Zealand white male rabbits. The animals were divided into three groups by implant material: CS10B, HA, and TCP. Radiographs we

Biomedical EngineeringEngineering
10
Article|32 citations·2010
Outcome of Spinal Fusion for Lumbar Degenerative Disease
Chang‐Bae Kong, Do-Whan Jeon, Bong‐Soon Chang, Jae Hyup Lee, Kyung‐Soo Suk, Jong‐Beom Park
SJR Q1Spine

Patients' satisfaction was not as high as expected after fusion for LDD. Therefore, the decision for performing a lumbar fusion in those patients must be done more carefully, and it should be explained more precisely that chronic pain may persist after spinal surgery.

Pathology and Forensic MedicineMedicine
11
Article|25 citations·2011
The efficacy of porous hydroxyapatite bone chip as an extender of local bone graft in posterior lumbar interbody fusion
Hyoungmin Kim, Choon‐Ki Lee, Jin S. Yeom, Jae Hyup Lee, Ki-Ho Lee, Bong‐Soon Chang
SJR Q1European Spine JournalOA
Pathology and Forensic MedicineMedicine
12
Article|23 citations·2020
A Long-Term Follow-up, Multicenter, Comparative Study of the Radiologic, and Clinical Results Between a CaO-SiO2-P2O5-B2O3 Bioactive Glass Ceramics (BGS-7) Intervertebral Spacer and Titanium Cage in 1-Level Posterior Lumbar Interbody Fusion
Jae Hyup Lee, Sun Ki Kim, Sung Shik Kang, Seung Jung Han, Choon‐Ki Lee, Bong‐Soon Chang
SJR Q1Clinical Spine Surgery A Spine PublicationOA

STUDY DESIGN: This is a prospective, stratified randomized, multicenter, 4-year follow-up study. OBJECTIVE: The authors aimed to evaluate the long-term clinical efficacy and safety of CaO-SiO2-P2O5-B2O3 glass ceramics (BGS-7) spacers in 1-level posterior lumbar interbody fusion (PLIF) at a 4-year follow-up. SUMMARY OF BACKGROUND DATA: According to 1-year follow-up results, BGS-7 spacer showed similar fusion rates and clinical outcomes compared with titanium cage. A long-term follow-up study beyo

Pathology and Forensic MedicineMedicine
13
Article|13 citations·2011
Optimal Trajectory for the Occipital Condylar Screw
Joon O. Lee, Jacob M. Buchowski, Kyoung M. Lee, Kun Woo Park, Bong‐Soon Chang, Choon‐Ki Lee, K. Daniel Riew, Jin S. Yeom
SJR Q1Spine

Screw placement is feasible in up to 93% of the occipital condyles. The lateral and the middle entry points are significantly better than the medial entry point. Selection between the middle and the lateral entry points should be individualized taking into account local anatomic variation. Because the medial angulation of these screws is highly variable, preoperative 3-dimensional CT evaluation and possibly even intraoperative navigation may be required.

SurgeryMedicine
14
Article|10 citations·2020
Sagittal Alignment in Patients with Thoracic Myelopathy Caused by the Ossification of the Ligamentum Flavum
Sam Yeol Chang, Yeonho Kim, Jun‐Ho Kim, Hyoungmin Kim, Ho‐Joong Kim, Jin S. Yeom, Choon‐Ki Lee, Bong‐Soon Chang
SJR Q1Spine

STUDY DESIGN: Retrospective case-control study. OBJECTIVE: The aim of this study was to describe and compare the sagittal spinal alignment between patients with and without the ossification of the ligamentum flavum in the thoracic spine (TOLF). SUMMARY OF BACKGROUND DATA: Although mechanical factors play an important role in the development of TOLF, limited evidence exists on the association of sagittal spinal alignment and TOLF in the literature. METHODS: The present study assessed the preopera

SurgeryMedicine
15
Article|9 citations·2017
Morphological changes of vertebral compression fracture with intra-vertebral cleft treated with percutaneous vertebroplasty
Sang‐Min Park, Jae-Woo Park, Hyoungmin Kim, Ho‐Joong Kim, Jin S. Yeom, Choon‐Ki Lee, Bong‐Soon Chang
SJR Q2Journal of Orthopaedic Science
SurgeryMedicine

Research Areas

SurgeryPathology and Forensic MedicineBiomedical EngineeringPharmacologyPhysiologyRheumatology

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